Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia

dc.contributor.authorJungmann, Carolinen
dc.contributor.authorHoughton, Caroline Gauguinen
dc.contributor.authorNielsen, Frederik Gothen
dc.contributor.authorPackeiser, Eva-Mariaen
dc.contributor.authorKörber, Hannaen
dc.contributor.authorReichler, Iris M.en
dc.contributor.authorBalogh, Orsolyaen
dc.contributor.authorGoericke-Pesch, Sandraen
dc.date.accessioned2022-11-10T18:44:45Zen
dc.date.available2022-11-10T18:44:45Zen
dc.date.issued2022-11-06en
dc.date.updated2022-11-10T14:27:57Zen
dc.description.abstractAn altered oxytocin and progesterone receptor (<i>OXTR</i> and <i>PGR</i>, respectively) expression was postulated in canine uterine inertia (UI), which is the lack of functional myometrial contractions. <i>OXTR</i> and <i>PGR</i> expressions were compared in uterine tissue obtained during C-section due to primary UI (PUI; <i>n</i> = 12) and obstructive dystocia (OD, <i>n</i> = 8). In PUI, the influence of litter size was studied (small/normal/large litter: PUI-S/N/L: <i>n</i> = 5/4/3). Staining intensity in immunohistochemistry was scored for the longitudinal and circular myometrial layer and summarized per dog (IP-Myoscore). Mean P4 did not differ significantly between PUI (<i>n</i> = 9) and OD (<i>n</i> = 7). <i>OXTR</i> and <i>PGR</i> expressions (ratios) were significantly higher in PUI (<i>OXTR</i>: <i>p</i> = 0.0019; <i>PGR</i>: <i>p</i> = 0.0339), also for <i>OXTR</i> in PUI-N versus OD (<i>p</i> = 0.0034). A trend for a higher <i>PGR</i> IP-Myoscore was identified (PUI-N vs. OD, <i>p</i> = 0.0626) as well as an influence of litter size (lowest <i>PGR</i>-Myoscore in PUI-L, <i>p</i> = 0.0391). In conclusion, PUI was not related to higher P4, but potentially increased <i>PGR</i> availability compared to OD. It remains to be clarified whether <i>OXTR</i> is upregulated in PUI due to a counterregulatory mechanism to overcome myometrial quiescence or downregulated in OD due to physiological slow <i>OXTR</i> desensitization associated with an advanced duration of labor. Identified <i>OXTR</i> differences between myometrial layers indicate the need for further research.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJungmann, C.; Houghton, C.G.; Nielsen, F.G.; Packeiser, E.-M.; Körber, H.; Reichler, I.M.; Balogh, O.; Goericke-Pesch, S. Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia. Int. J. Mol. Sci. 2022, 23, 13601.en
dc.identifier.doihttps://doi.org/10.3390/ijms232113601en
dc.identifier.urihttp://hdl.handle.net/10919/112567en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleInvolvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertiaen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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