Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia
| dc.contributor.author | Jungmann, Carolin | en |
| dc.contributor.author | Houghton, Caroline Gauguin | en |
| dc.contributor.author | Nielsen, Frederik Goth | en |
| dc.contributor.author | Packeiser, Eva-Maria | en |
| dc.contributor.author | Körber, Hanna | en |
| dc.contributor.author | Reichler, Iris M. | en |
| dc.contributor.author | Balogh, Orsolya | en |
| dc.contributor.author | Goericke-Pesch, Sandra | en |
| dc.date.accessioned | 2022-11-10T18:44:45Z | en |
| dc.date.available | 2022-11-10T18:44:45Z | en |
| dc.date.issued | 2022-11-06 | en |
| dc.date.updated | 2022-11-10T14:27:57Z | en |
| dc.description.abstract | An altered oxytocin and progesterone receptor (<i>OXTR</i> and <i>PGR</i>, respectively) expression was postulated in canine uterine inertia (UI), which is the lack of functional myometrial contractions. <i>OXTR</i> and <i>PGR</i> expressions were compared in uterine tissue obtained during C-section due to primary UI (PUI; <i>n</i> = 12) and obstructive dystocia (OD, <i>n</i> = 8). In PUI, the influence of litter size was studied (small/normal/large litter: PUI-S/N/L: <i>n</i> = 5/4/3). Staining intensity in immunohistochemistry was scored for the longitudinal and circular myometrial layer and summarized per dog (IP-Myoscore). Mean P4 did not differ significantly between PUI (<i>n</i> = 9) and OD (<i>n</i> = 7). <i>OXTR</i> and <i>PGR</i> expressions (ratios) were significantly higher in PUI (<i>OXTR</i>: <i>p</i> = 0.0019; <i>PGR</i>: <i>p</i> = 0.0339), also for <i>OXTR</i> in PUI-N versus OD (<i>p</i> = 0.0034). A trend for a higher <i>PGR</i> IP-Myoscore was identified (PUI-N vs. OD, <i>p</i> = 0.0626) as well as an influence of litter size (lowest <i>PGR</i>-Myoscore in PUI-L, <i>p</i> = 0.0391). In conclusion, PUI was not related to higher P4, but potentially increased <i>PGR</i> availability compared to OD. It remains to be clarified whether <i>OXTR</i> is upregulated in PUI due to a counterregulatory mechanism to overcome myometrial quiescence or downregulated in OD due to physiological slow <i>OXTR</i> desensitization associated with an advanced duration of labor. Identified <i>OXTR</i> differences between myometrial layers indicate the need for further research. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Jungmann, C.; Houghton, C.G.; Nielsen, F.G.; Packeiser, E.-M.; Körber, H.; Reichler, I.M.; Balogh, O.; Goericke-Pesch, S. Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia. Int. J. Mol. Sci. 2022, 23, 13601. | en |
| dc.identifier.doi | https://doi.org/10.3390/ijms232113601 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/112567 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | dog | en |
| dc.subject | dystocia | en |
| dc.subject | uterine inertia | en |
| dc.subject | oxytocin receptor | en |
| dc.subject | progesterone receptor | en |
| dc.title | Involvement of Oxytocin and Progesterone Receptor Expression in the Etiology of Canine Uterine Inertia | en |
| dc.title.serial | International Journal of Molecular Science | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |