Responses in splanchnic and mammary amino acid metabolism to short-term graded removal of methionine in lactating goats

Simple item page
dc.contributor.authorLi, Yantaoen
dc.contributor.authorHanigan, Mark D.en
dc.contributor.authorLin, Xueyanen
dc.contributor.authorHu, Zhiyongen
dc.contributor.authorYan, Zhenguien
dc.contributor.authorHou, Qiulingen
dc.contributor.authorWang, Yunen
dc.contributor.authorWang, Zhonghuaen
dc.date.accessioned2023-06-22T13:12:42Zen
dc.date.available2023-06-22T13:12:42Zen
dc.date.issued2023-06en
dc.description.abstractFour multi-catheterized lactating goats were used in a 4 x 4 Latin square experiment to investigate the responses of amino acid metabolism in portal-drained viscera (PDV), liver, and mammary glands to short-term varying supplies of methionine (Met). During the last 45 h in each experimental period, goats were fasted for 12 h and then abomasally infused with an amino acid (AA) mixture plus glucose for 33 h. Treatments consisted of graded removal of Met from an infused AA mixture to achieve Met content in the infusate of 100% (complete), 60%, 30%, or 0% that in casein. Graded Met removal decreased the pro-duction of milk, milk protein, lactose, and fat linearly whilst also decreasing arterial Met concentration linearly (P < 0.05). Meanwhile, net PDV uptake and liver removal of Met decreased linearly (P < 0.05) due to decreased Met affinity of PDV and liver (P < 0.05). Net mammary uptake of Met (P > 0.1) was maintained as Met supply declined. This was achieved through increased mammary affinity (P < 0.05) and increased mammary blood flow (P < 0.05) totally offsetting the negative effect of decreased circu-lating Met concentration. Graded removal of Met from the infusate linearly decreased mammary uptake -to-milk output ratios of Met (P < 0.05) and tended to decrease essential amino acid (EAA) linearly (0.05 < P < 0.1). Treatments also linearly decreased circulating concentration of prolactin and linearly increased insulin concentration (P < 0.05). In conclusion, results of the present study indicated there were several mechanisms used to mitigate a Met deficiency, including reduced catabolism of Met in PDV, liver, and peripheral tissue (including mammary glands) and a linear increase in mammary blood flow. The observed decreases in milk protein production as Met supply decreased appear to be a result of regulatory events which may have been driven by decreased circulating prolactin, rather than as a result of decreased mammary Met uptake.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.description.notesThe work is funded by National Natural Science Foundation of China under project number 31772623 and by China Agriculture Research System of MOF and MARA.en
dc.description.sponsorshipNational Natural Science Foundation of China [31772623]; China Agriculture Research System of MOF and MARAen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.aninu.2023.01.006en
dc.identifier.eissn2405-6545en
dc.identifier.issn2405-6383en
dc.identifier.pmid37123619en
dc.identifier.urihttp://hdl.handle.net/10919/115481en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherKeai Publishingen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMethionineen
dc.subjectLactating goaten
dc.subjectMilk proteinen
dc.subjectAmino aciden
dc.subjectSplanchnic tissueen
dc.titleResponses in splanchnic and mammary amino acid metabolism to short-term graded removal of methionine in lactating goatsen
dc.title.serialAnimal Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S2405654523000069-main.pdf
Size:
509.72 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Scholarly Works, School of Animal Sciences