Timing without coding: How do long non-coding RNAs regulate circadian rhythms?

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dc.contributor.authorMosig, Rebecca A.en
dc.contributor.authorKojima, Shihokoen
dc.date.accessioned2023-01-18T14:28:08Zen
dc.date.available2023-01-18T14:28:08Zen
dc.date.issued2022-06-01en
dc.date.updated2023-01-17T16:50:53Zen
dc.description.abstractLong non-coding RNAs (lncRNAs) are a new class of regulatory RNAs that play important roles in disease development and a variety of biological processes. Recent studies have underscored the importance of lncRNAs in the circadian clock system and demonstrated that lncRNAs regulate core clock genes and the core clock machinery in mammals. In this review, we provide an overview of our current understanding of how lncRNAs regulate the circadian clock without coding a protein. We also offer additional insights into the challenges in understanding the functions of lncRNAs and other unresolved questions in the field. We do not cover other regulatory ncRNAs even though they also play important roles; readers are highly encouraged to refer to other excellent reviews on this topic.en
dc.description.versionAccepted versionen
dc.format.extentPages 79-86en
dc.format.extent8 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.semcdb.2021.04.020en
dc.identifier.eissn1096-3634en
dc.identifier.issn1084-9521en
dc.identifier.orcidKojima, Shihoko [0000-0001-9579-7830]en
dc.identifier.otherS1084-9521(21)00093-8 (PII)en
dc.identifier.pmid34116930en
dc.identifier.urihttp://hdl.handle.net/10919/113233en
dc.identifier.volume126en
dc.language.isoenen
dc.publisherAcademic Press-Elsevieren
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000799035500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLong non-coding RNAen
dc.subjectAntisense transcripten
dc.subjectCircadian rhythmsen
dc.subjectMolecular clocken
dc.subjectPINEAL CLOCK EXPRESSIONen
dc.subjectGENE-EXPRESSIONen
dc.subjectTRANSCRIPTIONAL ARCHITECTUREen
dc.subjectANTISENSE RNAen
dc.subjectEVOLUTIONen
dc.subjectREVEALSen
dc.subjectROLESen
dc.subjectINDUCTIONen
dc.subjectLANDSCAPEen
dc.subjectMPER1en
dc.subjectNeurosciencesen
dc.subjectBiotechnologyen
dc.subjectGeneticsen
dc.subjectSleep Researchen
dc.subjectGeneric health relevanceen
dc.subject.meshAnimalsen
dc.subject.meshMammalsen
dc.subject.meshRNA, Untranslateden
dc.subject.meshCircadian Rhythmen
dc.subject.meshCircadian Clocksen
dc.subject.meshRNA, Long Noncodingen
dc.titleTiming without coding: How do long non-coding RNAs regulate circadian rhythms?en
dc.title.serialSeminars in Cell & Developmental Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2021-04-21en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen

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