Negative functional coupling between the right fronto-parietal and limbic resting state networks predicts increased self-control and later substance use onset in adolescence

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Date

2016-06-17

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Publisher

Elsevier

Abstract

Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal-limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the presentstudy examined functional network coupling between prefrontal and limbic systems and links toself-control and substance use onset in adolescents. Results suggest that negative network coupling(anti-correlated temporal dynamics) between the right fronto-parietal and limbic resting state net-works is associated with greater self-control and later substance use onset in adolescents. These findings increase our understanding of the developmental importance of prefrontal-limbic circuitry for adolescent substance use at the resting-state network level.

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Keywords

Adolescence, Risk-taking behavior, Resting-state fMRI, Independent component analysis (ICA), Fronto-parietal network (FPN), Limbic network, Intrinsic network connectivity

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