Service-based analysis of biological pathways

dc.contributor.authorZheng, Georgeen
dc.contributor.authorBouguettaya, Athmanen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2012-08-24T11:34:50Zen
dc.date.available2012-08-24T11:34:50Zen
dc.date.issued2009-10-01en
dc.date.updated2012-08-24T11:34:50Zen
dc.description.abstractBackground Computer-based pathway discovery is concerned with two important objectives: pathway identification and analysis. Conventional mining and modeling approaches aimed at pathway discovery are often effective at achieving either objective, but not both. Such limitations can be effectively tackled leveraging a Web service-based modeling and mining approach. Results Inspired by molecular recognitions and drug discovery processes, we developed a Web service mining tool, named PathExplorer, to discover potentially interesting biological pathways linking service models of biological processes. The tool uses an innovative approach to identify useful pathways based on graph-based hints and service-based simulation verifying user's hypotheses. Conclusion Web service modeling of biological processes allows the easy access and invocation of these processes on the Web. Web service mining techniques described in this paper enable the discovery of biological pathways linking these process service models. Algorithms presented in this paper for automatically highlighting interesting subgraph within an identified pathway network enable the user to formulate hypothesis, which can be tested out using our simulation algorithm that are also described in this paper.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBMC Bioinformatics. 2009 Oct 01;10(Suppl 10):S6en
dc.identifier.doihttps://doi.org/10.1186/1471-2105-10-S10-S6en
dc.identifier.urihttp://hdl.handle.net/10919/18859en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderGeorge Zheng et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleService-based analysis of biological pathwaysen
dc.title.serialBMC Bioinformaticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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