The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma

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dc.contributor.authorPridham, Kevin J.en
dc.contributor.authorVarghese, Robin T.en
dc.contributor.authorSheng, Zhien
dc.date.accessioned2018-03-14T15:08:35Zen
dc.date.available2018-03-14T15:08:35Zen
dc.date.issued2017-12-15en
dc.description.abstractPhosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) plays a critical role in the pathogenesis of cancer including glioblastoma, the most common and aggressive form of brain cancer. Targeting the PI3K pathway to treat glioblastoma has been tested in the clinic with modest effect. In light of the recent finding that PI3K catalytic subunits (PIK3CA/p110 alpha, PIK3CB/p110 beta, PIK3CD/p110 delta, and PIK3CG/p110 gamma) are not functionally redundant, it is imperative to determine whether these subunits play divergent roles in glioblastoma and whether selectively targeting PI3K catalytic subunits represents a novel and effective strategy to tackle PI3K signaling. This article summarizes recent advances in understanding the role of PI3K catalytic subunits in glioblastoma and discusses the possibility of selective blockade of one PI3K catalytic subunit as a treatment option for glioblastoma.en
dc.description.versionPublished versionen
dc.format.extent? - ? (8) page(s)en
dc.identifier.doihttps://doi.org/10.3389/fonc.2017.00312en
dc.identifier.issn2234-943Xen
dc.identifier.orcidSheng, Z [0000-0002-0029-8666]en
dc.identifier.urihttp://hdl.handle.net/10919/82497en
dc.identifier.volume7en
dc.languageEnglishen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418035800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectOncologyen
dc.subjectphosphatidylinositol-4,5-bisphosphate 3-kinaseen
dc.subjectglioblastomaen
dc.subjectclass IA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunitsen
dc.subjectPIK3CAen
dc.subjectPIK3CBen
dc.subjectPIK3CDen
dc.subjectCHRONIC LYMPHOCYTIC-LEUKEMIAen
dc.subjectREPORT PRIMARY BRAINen
dc.subjectRECURRENT GLIOBLASTOMAen
dc.subjectUNITED-STATESen
dc.subjectPIK3CA GENEen
dc.subjectPHASE-IIen
dc.subjectPHOSPHOINOSITIDE 3-KINASEen
dc.subjectMETABOLIC-REGULATIONen
dc.subjectP110-ALPHA ISOFORMen
dc.subjectONCOGENIC MUTATIONen
dc.titleThe Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastomaen
dc.title.serialFrontiers in Oncologyen
dc.typeArticle - Refereeden
dc.type.otherReviewen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Facultyen

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