Hemophagocytic syndrome in a cat

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dc.contributor.authorWilkinson, Ashley R.en
dc.contributor.authorCarr, Susan V.en
dc.contributor.authorKlahn, Shawna L.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorHanks, Cory R.en
dc.date.accessioned2021-11-03T14:11:53Zen
dc.date.available2021-11-03T14:11:53Zen
dc.date.issued2018-07en
dc.date.updated2021-11-03T14:11:50Zen
dc.description.abstractCase summary: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on serial complete blood counts. Antibodies against feline immunodeficiency virus (FIV) were detected, but vaccination for FIV occurred previously. Echocardiography revealed biatrial and biventricular enlargement, left ventricular hypertrophy and pericardial effusion. Splenomegaly was present on abdominal ultrasound and cytological evaluation revealed macrophagic infiltration with erythrophagocytosis. Cytological evaluation of the bone marrow revealed similar findings. Histopathology of the spleen confirmed hemophagocytosis with no evidence of malignancy. A presumptive diagnosis of hemophagocytic syndrome was made. PCR testing for FIV on the splenic tissue was negative. The cat was treated with lomustine. Disease progression occurred approximately 6 months after diagnosis and the cat was euthanized. Relevance and novel information: To our knowledge, this is one of the few reports describing the diagnosis of hemophagocytic syndrome in a cat.en
dc.description.versionPublished versionen
dc.format.extentPages 2055116918795023en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1177/2055116918795023en
dc.identifier.eissn2055-1169en
dc.identifier.issn2055-1169en
dc.identifier.issue2en
dc.identifier.orcidDervisis, Nikolaos [0000-0003-2869-1483]en
dc.identifier.otherPMC6113740en
dc.identifier.other10.1177_2055116918795023 (PII)en
dc.identifier.pmid30181894en
dc.identifier.urihttp://hdl.handle.net/10919/106500en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherSAGEen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/30181894en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAnemiaen
dc.subjectbone marrowen
dc.subjectcardiomyopathyen
dc.subjecthemophagocytic syndromeen
dc.subjectimmune-mediated diseasesen
dc.titleHemophagocytic syndrome in a caten
dc.title.serialJFMS open reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherCase Reportsen
dc.type.othercase-reporten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

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