Iron homeostasis and plant immune responses: Recent insights and translational implications

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dc.contributor.authorHerlihy, John H.en
dc.contributor.authorLong, Terri A.en
dc.contributor.authorMcDowell, John M.en
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2021-02-16T13:49:46Zen
dc.date.available2021-02-16T13:49:46Zen
dc.date.issued2020-09-25en
dc.description.abstractIron metabolism and the plant immune system are both critical for plant vigor in natural ecosystems and for reliable agricultural productivity. Mechanistic studies of plant iron home-ostasis and plant immunity have traditionally been carried out in isolation from each other; however, our growing understanding of both processes has uncovered significant connections. For example, iron plays a critical role in the generation of reactive oxygen intermediates during immunity and has been recently implicated as a critical factor for immune-initiated cell death via ferroptosis. Moreover, plant iron stress triggers immune activation, suggesting that sensing of iron depletion is a mechanism by which plants recognize a pathogen threat. The iron deficiency response engages hormone signaling sectors that are also utilized for plant immune signaling, providing a probable explanation for iron-immunity cross-talk. Finally, interference with iron acquisition by pathogens might be a critical component of the immune response. Efforts to address the global burden of iron deficiency-related anemia have focused on classical breeding and transgenic approaches to develop crops biofortified for iron content. However, our improved mechanistic understanding of plant iron metabolism suggests that such alterations could promote or impede plant immunity, depending on the nature of the alteration and the virulence strategy of the pathogen. Effects of iron biofortification on disease resistance should be evaluated while developing plants for iron biofortification.en
dc.description.notesThis article was supported by a joint collaborative grant (to J. M. M. and T. A. L.) from the Colleges of Agriculture and Life Sciences at Virginia Tech and North Carolina State University. T. A. L. was supported by the National Science Foundation and the Biotechnology and Biological Sciences Research Council (BBSRC) (Grant NSF MCB-1517058), the United States Department of Agriculture National Institute of Food and Agriculture, the Hatch Project (Accession Number 101090), and the North Carolina State University North Carolina Agriculture and Life Sciences Research Foundation.en
dc.description.sponsorshipColleges of Agriculture and Life Sciences at Virginia Tech and North Carolina State University; National Science FoundationNational Science Foundation (NSF); Biotechnology and Biological Sciences Research Council (BBSRC)Biotechnology and Biological Sciences Research Council (BBSRC) [NSF MCB-1517058]; United States Department of Agriculture National Institute of Food and Agriculture, the Hatch Project [101090]; North Carolina State University North Carolina Agriculture and Life Sciences Research Foundationen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1074/jbc.REV120.010856en
dc.identifier.eissn1083-351Xen
dc.identifier.issn0021-9258en
dc.identifier.issue39en
dc.identifier.pmid32732287en
dc.identifier.urihttp://hdl.handle.net/10919/102379en
dc.identifier.volume295en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectArabidopsis thalianaen
dc.subjecthost-pathogen interactionen
dc.subjectiron metabolismen
dc.subjectmetal homeostasisen
dc.subjectoxygen radicalsen
dc.subjectplant defenseen
dc.subjectplant hormoneen
dc.titleIron homeostasis and plant immune responses: Recent insights and translational implicationsen
dc.title.serialJournal of Biological Chemistryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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