Potential of Stem Cell-Based Therapy for Ischemic Stroke

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dc.contributor.authorMarei, Hany E.en
dc.contributor.authorHasan, A.en
dc.contributor.authorRizzi, R.en
dc.contributor.authorAlthani, A.en
dc.contributor.authorAfifi, N.en
dc.contributor.authorCenciarelli, C.en
dc.contributor.authorCaceci, Thomasen
dc.contributor.authorShuaib, Ashfaqen
dc.date.accessioned2019-10-30T13:05:07Zen
dc.date.available2019-10-30T13:05:07Zen
dc.date.issued2018-02-06en
dc.description.abstractIschemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.en
dc.description.notesThis project is funded by Qatar University Grant # GCC-2017-004.en
dc.description.sponsorshipQatar University Grant [GCC-2017-004]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fneur.2018.00034en
dc.identifier.issn1664-2295en
dc.identifier.other34en
dc.identifier.pmid29467713en
dc.identifier.urihttp://hdl.handle.net/10919/95211en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectstem cellen
dc.subjectmesenchymal stem cellen
dc.subjectneural stem cellen
dc.subjectinduced pluripotent stem cellsen
dc.subjectischemic strokeen
dc.titlePotential of Stem Cell-Based Therapy for Ischemic Strokeen
dc.title.serialFrontiers in Neurologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Scholarly Works, Biomedical Sciences and Pathobiology
Destination Area: Adaptive Brain and Behavior (ABB)