The genetic and biological basis of feed efficiency in mid-lactation Holstein dairy cows

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dc.contributor.authorHardie, L. C.en
dc.contributor.authorVandeHaar, M. J.en
dc.contributor.authorTempelman, R. J.en
dc.contributor.authorWeigel, K. A.en
dc.contributor.authorArmentano, L. E.en
dc.contributor.authorWiggans, G. R.en
dc.contributor.authorVeerkamp, R. F.en
dc.contributor.authorde Haas, Y.en
dc.contributor.authorCoffey, M. P.en
dc.contributor.authorConnor, E. E.en
dc.contributor.authorHanigan, Mark D.en
dc.contributor.authorStaples, C. R.en
dc.contributor.authorWang, Z.en
dc.contributor.authorDekkers, J. C. M.en
dc.contributor.authorSpurlock, D. M.en
dc.contributor.departmentDairy Scienceen
dc.date.accessioned2020-03-18T19:01:44Zen
dc.date.available2020-03-18T19:01:44Zen
dc.date.issued2017-11en
dc.description.abstractThe objective of this study was to identify genomic regions and candidate genes associated with feed efficiency in lactating Holstein cows. In total, 4,916 cows with actual or imputed genotypes for 60,671 single nucleotide polymorphisms having individual feed intake, milk yield, milk composition, and body weight records were used in this study. Cows were from research herds located in the United States, Canada, the Netherlands, and the United Kingdom. Feed efficiency, defined as residual feed intake (RFI), was calculated within location as the residual of the regression of dry matter intake (DMI) on milk energy (MilkE), metabolic body weight (MBW), change in body weight, and systematic effects. For RFI, DMI, MilkE, and MBW, bivariate analyses were performed considering each trait as a separate trait within parity group to estimate variance components and genetic correlations between them. Animal relationships were established using a genomic relationship matrix. Genome-wide association studies were performed separately by parity group for RFI, DMI, MilkE, and MBW using the Bayes B method with a prior assumption that 1% of single nucleotide polymorphisms have a nonzero effect. One-megabase windows with greatest percentage of the total genetic variation explained by the markers (TGVM) were identified, and adjacent windows with large proportion of the TGVM were combined and reanalyzed. Heritability estimates for RFI were 0.14 (+/- 0.03; +/- SE) in primiparous cows and 0.13 (+/- 0.03) in multiparous cows. Genetic correlations between primiparous and multiparous cows were 0.76 for RFI, 0.78 for DMI, 0.92 for MBW, and 0.61 for MilkE. No single 1-Mb window explained a significant proportion of the TGVM for RFI; however, after combining windows, significance was met on Bos taurus autosome 27 in primiparous cows, and nearly reached on Bos taurus autosome 4 in multiparous cows. Among other genes, these regions contain 6-3 adrenergic receptor and the physiological candidate gene, leptin, respectively. Between the 2 parity groups, 3 of the 10 windows with the largest effects on DMI neighbored windows affecting RFI, but were not in the top 10 regions for MilkE or MBW. This result suggests a genetic basis for feed intake that is unrelated to energy consumption required for milk production or expected maintenance as determined by MBW. In conclusion, feed efficiency measured as RFI is a polygenic trait exhibiting a dynamic genetic basis and genetic variation distinct from that underlying expected maintenance requirements and milk energy output.en
dc.description.adminPublic domain – authored by a U.S. government employeeen
dc.description.notesThis project received financial support from the USDA National Needs Graduate Fellowship Competitive Grant no. 2013-38420-20496 (Washington, DC) and the Agriculture and Food Research Initiative Competitive Grant no. 2011-68004-30340 (Washington, DC).en
dc.description.sponsorshipUSDA National Needs Graduate Fellowship Competitive Grant (Washington, DC) [2013-38420-20496]; Agriculture and Food Research Initiative Competitive Grant (Washington, DC) [2011-68004-30340]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3168/jds.2017-12604en
dc.identifier.eissn1525-3198en
dc.identifier.issn0022-0302en
dc.identifier.issue11en
dc.identifier.pmid28843688en
dc.identifier.urihttp://hdl.handle.net/10919/97358en
dc.identifier.volume100en
dc.language.isoenen
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectgenome-wide association studyen
dc.subjectresidual feed intakeen
dc.subjectfeed efficiencyen
dc.subjectdairyen
dc.titleThe genetic and biological basis of feed efficiency in mid-lactation Holstein dairy cowsen
dc.title.serialJournal of Dairy Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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