Biological Agent Sensing Integrated Circuit (BASIC): A New Complementary Metal-oxide-semiconductor (CMOS) Magnetic Biosensor System

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dc.contributor.authorZheng, Yien
dc.contributor.committeechairTront, Joseph G.en
dc.contributor.committeememberScales, Wayne A.en
dc.contributor.committeememberHa, Dong S.en
dc.contributor.committeememberSriranganathan, Nammalwaren
dc.contributor.committeememberSchaumont, Patrick R.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2014-06-11T08:00:37Zen
dc.date.available2014-06-11T08:00:37Zen
dc.date.issued2014-06-10en
dc.description.abstractFast and accurate diagnosis is always in demand by modern medical professionals and in the area of national defense. At present, limitations of testing speed, sample conditions, and levels of precision exist under current technologies, which are usually slow and involve testing the specimen under laboratory conditions. Typically, these methods also involve several biochemical processing steps and subsequent detection of low energy luminescence or electrical changes, all of which reduce the speed of the test as well as limit the precision. In order to solve these problems and improve the sensing performance, this project proposes an innovative CMOS magnetic biological sensor system for rapidly testing the presence of potential pathogens and bioterrorism agents (zoonotic microorganisms) both in specimens and especially in the environment. The sensor uses an electromagnetic detection mechanism to measure changes in the number of microorganisms--tagged by iron nanoparticles--that are placed on the surface of an integrated circuit (IC) chip. Measured magnetic effects are transformed into electronic signals that count the number and type of organisms present. This biosensor introduces a novel design of a conical-shaped inductor, which achieves ultra-accuracy of sensing biological pathogens. The whole system is integrated on a single chip based on the fabrication process of IBM 180 nm (CMOS_IBM_7RF), which makes the sensor small-sized, portable, high speed, and low cost. The results of designing, simulating, and fabricating the sensor are reported in this dissertation.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.othervt_gsexam:2990en
dc.identifier.urihttp://hdl.handle.net/10919/48892en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectBiohazarden
dc.subjectAntibody and antigenen
dc.subjectPathogenen
dc.subjectIron nanoparticleen
dc.subjectCMOSen
dc.subjectIntegrated circuiten
dc.subjectConical-shaped inductoren
dc.subjectUniform magnetic fielden
dc.subjectMagnetic sensoren
dc.subjectLC oscillatoren
dc.subjectFrequency counteren
dc.subjectPrototypeen
dc.subjectAntenna effecten
dc.titleBiological Agent Sensing Integrated Circuit (BASIC): A New Complementary Metal-oxide-semiconductor (CMOS) Magnetic Biosensor Systemen
dc.typeDissertationen
thesis.degree.disciplineComputer Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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