Insecticidal and repellent properties of novel trifluoromethylphenyl amides II

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dc.contributor.authorTsikolia, Maiaen
dc.contributor.authorBernier, Ulrich R.en
dc.contributor.authorAgramonte, Natasha M.en
dc.contributor.authorEstep, Alden S.en
dc.contributor.authorBecnel, James J.en
dc.contributor.authorTabanca, Nurhayaten
dc.contributor.authorLinthicum, Kenneth J.en
dc.contributor.authorGross, Aaron D.en
dc.contributor.authorGuerin, Patrick M.en
dc.contributor.authorKrober, Thomasen
dc.contributor.authorBloomquist, Jeffrey R.en
dc.contributor.departmentEntomologyen
dc.date.accessioned2020-03-10T17:47:46Zen
dc.date.available2020-03-10T17:47:46Zen
dc.date.issued2018-10en
dc.description.abstractThis project focused on the design, synthesis, and testing of trifluoromethylphenyl amides (TFMPAs) as potential mosquitocides and repellents. Fourteen compounds were evaluated for toxicity against larvae and adults of Aedes aegypti. Several compounds were toxic against Aedes aegypti (larval, adult and feeding bioassays) and Drosophila melanogaster (glass-surface contact assay), but were much less toxic than fipronil, with toxicity ratios ranging from 100-fold in the larval assay to 100,000-fold for topical application to adult insects. In repellency bioassays to determine minimum effective dosage (MED), compound N-(2,6-dichloro-4(trifluoromethyl)phenyl)-2,2,3,3,3-pentafluoropropanamide (7b) repelled Ae. aegypti females at lower concentration, 0.017 (+/- 0.006) mu mol/cm(2), than N, N-diethyl-meta-toluamide (DEET) 0.026 (+/- 0.005) mu mol/cm(2). 2-Chloro-N-(3-(trifluoromethyl)phenyl)acetamide (6a) performed better than DEET against two species of mosquitoes: it repelled Ae. aegypti females at 0.013 (+/- 0.006) mu mol/cm(2) and Anopheles gambiae females (in a warm body repellent assay), at a standard exposure of 2 nmol/cm(2). These studies revealed novel active structures that could further lead to compounds with better repellent activity.en
dc.description.adminPublic domain – authored by a U.S. government employeeen
dc.description.notesThis work was supported by the Deployed War-Fighter Protection Research Program and funded by the United States Department of Defense through the Armed Forces Pest Management Board [Agreement 60-0208-4-001 and under USDA Specific Cooperative Agreements 58-0208-0-068 and 58-0208-5-001].en
dc.description.sponsorshipDeployed War-Fighter Protection Research Program; United States Department of Defense through the Armed Forces Pest Management BoardUnited States Department of Defense [60-0208-4-001]; United States Department of Defense through the Armed Forces Pest Management Board [USDA] [58-0208-0-068, 58-0208-5-001]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.pestbp.2018.08.006en
dc.identifier.eissn1095-9939en
dc.identifier.issn0048-3575en
dc.identifier.pmid30704711en
dc.identifier.urihttp://hdl.handle.net/10919/97303en
dc.identifier.volume151en
dc.language.isoenen
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectAedes aegyptien
dc.subjectAnopheles gambiaeen
dc.subjectDrosophila melanogasteren
dc.subjectMosquitoen
dc.titleInsecticidal and repellent properties of novel trifluoromethylphenyl amides IIen
dc.title.serialPesticide Biochemistry and Physiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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