VTechWorks staff will be away for the Thanksgiving holiday beginning at noon on Wednesday, November 27, through Friday, November 29. We will resume normal operations on Monday, December 2. Thank you for your patience.
 

Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders

Simple item page
dc.contributor.authorHodes, Georgia E.en
dc.contributor.departmentSchool of Neuroscienceen
dc.date.accessioned2018-04-18T13:18:57Zen
dc.date.available2018-04-18T13:18:57Zen
dc.date.issued2013en
dc.description.abstractWomen have a higher incidence of stress related disorders including depression and generalized anxiety disorder, and epigenetic mechanisms likely contribute to this sex difference. Evidence from preclinical research suggests that epigenetic mechanisms are responsible for both sexual dimorphism of brain regions and sensitivity of the stress response. Epigenetic modifications such as DNA methylation and histone modifications can occur transgenerationally, developmentally, or in response to environmental stimuli such as stress exposure. This review will provide an overview of the various forms of epigenetic modifications observed in the central nervous system and will explain how these mechanisms contribute to a sexually dimorphic brain. It will also discuss the ways in which epigenetic alterations coincide with, and functionally contribute to, the behavioral response to stress across the lifespan. Ultimately, this review will focus on novel research utilizing animal models to investigate sex differences in epigenetic mechanisms that influence susceptibility to stress. Exploration of this relationship reveals epigenetic mechanisms with the potential to explain sexual dimorphism in the occurrence of stress related disorders.en
dc.description.sponsorshipNIMH 1R01MH090264en
dc.description.sponsorshipNIDA 5TDA07135-28en
dc.description.sponsorshipBrain and Behavior Research Foundation NARSAD Young Investigator Awarden
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/2042-6410-4-1en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/82846en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherBMCen
dc.rightsCreative Commons Attribution 2.0 Genericen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en
dc.subjectEpigeneticsen
dc.subjectStressen
dc.subjectDepressionen
dc.subjectAnxietyen
dc.subjectAnimal modelsen
dc.subjectDNA methylationen
dc.subjectHistone modificationsen
dc.subjectSex differencesen
dc.titleSex, stress, and epigenetics: regulation of behavior in animal models of mood disordersen
dc.title.serialBiology of Sex Differencesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
HodesMoodDisorders2013.pdf
Size:
342.2 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Destination Area: Adaptive Brain and Behavior (ABB)
Journal Articles, BioMed Central and SpringerOpen
Scholarly Works, School of Neuroscience