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Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training

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dc.contributor.authorEikenberg, Joshua D.en
dc.contributor.authorSavla, Jyoti S.en
dc.contributor.authorMarinik, Elaina L.en
dc.contributor.authorDavy, Kevin P.en
dc.contributor.authorPownall, Johnen
dc.contributor.authorBaugh, Mary Elizabethen
dc.contributor.authorFlack, Kyle D.en
dc.contributor.authorBoshra, Soheiren
dc.contributor.authorWinett, Richard A.en
dc.contributor.authorDavy, Brenda M.en
dc.date.accessioned2017-01-08T21:23:51Zen
dc.date.available2017-01-08T21:23:51Zen
dc.date.issued2016-02-03en
dc.description.abstractPurpose To determine if prediabetes phenotype influences improvements in glucose homeostasis with resistance training (RT). Methods Older, overweight individuals with prediabetes (n = 159; aged 60±5 yrs; BMI 33±4 kg/m2) completed a supervised RT program twice per week for 12 weeks. Body weight and composition, strength, fasting plasma glucose, 2-hr oral glucose tolerance, and Matsuda-Defronza estimated insulin sensitivity index (ISI) were assessed before and after the intervention. Participants were categorized according to their baseline prediabetes phenotype as impaired fasting glucose only (IFG) (n = 73), impaired glucose tolerance only (IGT) (n = 21), or combined IFG and IGT (IFG/IGT) (n = 65). Results Chest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both p<0.05). Waist circumference (-1.0%; pre 109.3±10.3 cm, post 108.2±10.6 cm) and body fat (-0.6%; pre 43.7±6.8%, post 43.1±6.8%) declined, and lean body mass (+1.3%; pre 52.0±10.4 kg, post 52.7±10.7 kg) increased following the intervention. Fasting glucose concentrations did not change (p>0.05) following the intervention. However, 2-hr oral glucose tolerance improved in those with IGT (pre 8.94±0.72 mmol/l, post 7.83±1.11 mmol/l, p<0.05) and IFG/IGT (pre 9.66±1.11mmol/l, post 8.60±2.00 mmol/l) but not in those with IFG (pre 6.27±1.28mmol/l, post 6.33± 1.55 mmol/l). There were no significant changes in ISI or glucose area under the curve following the RT program. Conclusions RT without dietary intervention improves 2-hr oral glucose tolerance in individuals with prediabetes. However, the improvements in glucose homeostasis with RT appear limited to those with IGT or combined IFG and IGT.en
dc.description.versionPublished versionen
dc.format.extent? - ? (13) page(s)en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0148009en
dc.identifier.issn1932-6203en
dc.identifier.issue2en
dc.identifier.urihttp://hdl.handle.net/10919/74015en
dc.identifier.volume11en
dc.languageEnglishen
dc.publisherPLOSen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000369550200075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectimpaired fasting glucoseen
dc.subjecttype-2 diabetes-mellitusen
dc.subjectlife-style interventionen
dc.subjectrandomized controlled-trialen
dc.subjectglycemic controlen
dc.subjectinsulin sensitivityen
dc.subjectskeletal-muscleen
dc.subjectsample-sizeen
dc.subjecttoleranceen
dc.subjectexerciseen
dc.titlePrediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Trainingen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciencesen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciences/CLAHS T&R Facultyen
pubs.organisational-group/Virginia Tech/Liberal Arts and Human Sciences/Human Developmenten
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/Psychologyen

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