Leptomeningeal anastomoses: Mechanisms of pial collateral remodeling in ischemic stroke

Simple item page
dc.contributor.authorKaloss, Alexandra M.en
dc.contributor.authorTheus, Michelle H.en
dc.date.accessioned2022-08-01T12:51:19Zen
dc.date.available2022-08-01T12:51:19Zen
dc.date.issued2022-02-03en
dc.description.abstractArterial collateralization, as determined by leptomeningeal anastomoses or pial collateral vessels, is a well-established vital player in cerebral blood flow restoration and neurological recovery from ischemic stroke. A secondary network of cerebral collateral circulation apart from the Circle of Willis, exist as remnants of arteriole development that connect the distal arteries in the pia mater. Recent interest lies in understanding the cellular and molecular adaptations that control the growth and remodeling, or arteriogenesis, of these pre-existing collateral vessels. New findings from both animal models and human studies of ischemic stroke suggest a multi-factorial and complex, temporospatial interplay of endothelium, immune and vessel-associated cell interactions may work in concert to facilitate or thwart arteriogenesis. These valuable reports may provide critical insight into potential predictors of the pial collateral response in patients with large vessel occlusion and may aid in therapeutics to enhance collateral function and improve recovery from stroke. This article is categorized under: Neurological Diseases > Molecular and Cellular Physiologyen
dc.description.notesThis work was supported by NS112541 (MHT).en
dc.description.sponsorship[NS112541]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/wsbm.1553en
dc.identifier.issn2692-9368en
dc.identifier.othere1553en
dc.identifier.pmid35118835en
dc.identifier.urihttp://hdl.handle.net/10919/111411en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectarteriogenesisen
dc.subjectischemic strokeen
dc.subjectlarge vessel occlusionen
dc.subjectleptomeningeal anastomosesen
dc.subjectpial collateralen
dc.titleLeptomeningeal anastomoses: Mechanisms of pial collateral remodeling in ischemic strokeen
dc.title.serialWires Mechanisms of Diseaseen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
KalossLepto2022.pdf
Size:
2.19 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Scholarly Works, Biomedical Sciences and Pathobiology