Linking drug and food addiction via compulsive appetite

Simple item page
dc.contributor.authorLaque, Amandaen
dc.contributor.authorWagner, Grant E.en
dc.contributor.authorMatzeu, Alessandraen
dc.contributor.authorDe Ness, Genna L.en
dc.contributor.authorKerr, Tony M.en
dc.contributor.authorCarroll, Ayla M.en
dc.contributor.authorde Guglielmo, Giordanoen
dc.contributor.authorNedelescu, Herminaen
dc.contributor.authorBuczynski, Matthew W.en
dc.contributor.authorGregus, Ann M.en
dc.contributor.authorJhou, Thomas C.en
dc.contributor.authorZorrilla, Eric P.en
dc.contributor.authorMartin-Fardon, Remien
dc.contributor.authorKoya, Eisukeen
dc.contributor.authorRitter, Robert C.en
dc.contributor.authorWeiss, Friedberten
dc.contributor.authorSuto, Nobuyoshien
dc.date.accessioned2024-02-05T13:10:27Zen
dc.date.available2024-02-05T13:10:27Zen
dc.date.issued2022-06en
dc.description.abstractBackground and Purpose: ‘Food addiction’ is the subject of intense public and research interest. However, this nosology based on neurobehavioural similarities among obese individuals, patients with eating disorders and those with substance use disorders (drug addiction) remains controversial. We thus sought to determine which aspects of disordered eating are causally linked to preclinical models of drug addiction. We hypothesized that extensive drug histories, known to cause addiction-like brain changes and drug motivation in rats, would also cause addiction-like food motivation. Experimental Approach: Rats underwent extensive cocaine, alcohol, caffeine or obesogenic diet histories and were subsequently tested for punishment-resistant food self-administration or ‘compulsive appetite’, as a measure of addiction-like food motivation. Key Results: Extensive cocaine and alcohol (but not caffeine) histories caused compulsive appetite that persisted long after the last drug exposure. Extensive obesogenic diet histories also caused compulsive appetite, although neither cocaine nor alcohol histories caused excess calorie intake and bodyweight during abstinence. Hence, compulsive appetite and obesity appear to be dissociable, with the former sharing common mechanisms with preclinical drug addiction models. Conclusion and Implications: Compulsive appetite, as seen in subsets of obese individuals and patients with binge-eating disorder and bulimia nervosa (eating disorders that do not necessarily result in obesity), appears to epitomize ‘food addiction’. Because different drug and obesogenic diet histories caused compulsive appetite, overlapping dysregulations in the reward circuits, which control drug and food motivation independently of energy homeostasis, may offer common therapeutic targets for treating addictive behaviours across drug addiction, eating disorders and obesity.en
dc.description.versionAccepted versionen
dc.format.extentPages 2589-2609en
dc.format.extent21 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/bph.15797en
dc.identifier.eissn1476-5381en
dc.identifier.issn0007-1188en
dc.identifier.issue11en
dc.identifier.orcidBuczynski, Matthew [0000-0001-5931-7107]en
dc.identifier.pmid35023154en
dc.identifier.urihttps://hdl.handle.net/10919/117852en
dc.identifier.volume179en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35023154en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecteating disordersen
dc.subjectfood addictionen
dc.subjectsubstance use disordersen
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshRatsen
dc.subject.meshObesityen
dc.subject.meshSubstance-Related Disordersen
dc.subject.meshCocaineen
dc.subject.meshPharmaceutical Preparationsen
dc.subject.meshFeeding Behavioren
dc.subject.meshBehavior, Addictiveen
dc.subject.meshAppetiteen
dc.subject.meshFooden
dc.subject.meshFood Addictionen
dc.titleLinking drug and food addiction via compulsive appetiteen
dc.title.serialBritish Journal of Pharmacologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2021-10-21en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/School of Neuroscienceen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Linking drug and food addiction via compulsive appetite.pdf
Size:
513.27 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Plain Text
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, School of Neuroscience