Dynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cells

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dc.contributor.authorTavassoly, I.en
dc.contributor.authorParmar, J.en
dc.contributor.authorShajahan-Haq, A. N.en
dc.contributor.authorClarke, R.en
dc.contributor.authorBaumann, William T.en
dc.contributor.authorTyson, John J.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2016-12-09T21:25:10Zen
dc.date.available2016-12-09T21:25:10Zen
dc.date.issued2015-04en
dc.description.abstractAutophagy is a conserved biological stress response in mammalian cells that is responsible for clearing damaged proteins and organelles from the cytoplasm and recycling their contents via the lysosomal pathway. In cases of mild stress, autophagy acts as a survival mechanism, while in cases of severe stress cells may switch to programmed cell death. Understanding the decision process that moves a cell from autophagy to apoptosis is important since abnormal regulation of autophagy occurs in many diseases, including cancer. To integrate existing knowledge about this decision process into a rigorous, analytical framework, we built a mathematical model of cell fate decisions mediated by autophagy. Our dynamical model is consistent with existing quantitative measurements of autophagy and apoptosis in rat kidney proximal tubular cells responding to cisplatin-induced stress.en
dc.description.versionPublished versionen
dc.format.extent263 - 272 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/psp4.29en
dc.identifier.issue4en
dc.identifier.urihttp://hdl.handle.net/10919/73617en
dc.identifier.volume4en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26225250en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleDynamic Modeling of the Interaction Between Autophagy and Apoptosis in Mammalian Cellsen
dc.title.serialCPT Pharmacometrics Syst Pharmacolen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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