Millet is one of the main agricultural crops of the Region of Mopti, Mali. Rainfall and poor soil fertility are the main factors impacting millet yields. The present study is a contribution to the restoration of soil fertility and increasing millet yields in the region. Two types of activities were carried out: one a survey and the second an introduction of technical itineraries for soil fertilization in a rural environment. The different results of the tests of soil fertility management technical routes in farms showed that a system of mixed production, associating agriculture and animal husbandry and using Natural Phosphates can constitute a sustainable alternative to the continuous cultivation of cereals leading to a loss of soils fertility.