Label-free DNA sequence detection using oligonucleotide functionalized optical fiber

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dc.contributorVirginia Techen
dc.contributor.authorWang, X. W.en
dc.contributor.authorCooper, K. L.en
dc.contributor.authorWang, Anboen
dc.contributor.authorXu, J. C.en
dc.contributor.authorWang, Z. A.en
dc.contributor.authorZhang, Y.en
dc.contributor.authorTu, Zhijian Jakeen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentMechanical Engineeringen
dc.contributor.departmentBiochemistryen
dc.date.accessed2014-03-27en
dc.date.accessioned2014-04-16T14:16:42Zen
dc.date.available2014-04-16T14:16:42Zen
dc.date.issued2006-10-01en
dc.description.abstractThe authors present a label-free method for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly technique. Hybridization of target DNA with complementary capture DNA increases the optical thickness of the fiber tip. This phenomenon can be detected by demodulation of the spectrum of a Fabry-Perot cavity fabricated in the optical fiber. Experimental results demonstrate sequence specificity and sensitivity to nanogram quantities of target DNA sequences with short (similar to 5 min) hybridization time. (c) 2006 American Institute of Physics.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWang, Xingwei; Cooper, Kristie L.; Wang, Anbo; et al., "Label-free DNA sequence detection using oligonucleotide functionalized optical fiber," Appl. Phys. Lett. 89, 163901 (2006); http://dx.doi.org/10.1063/1.2364459en
dc.identifier.doihttps://doi.org/10.1063/1.2364459en
dc.identifier.issn0003-6951en
dc.identifier.urihttp://hdl.handle.net/10919/47385en
dc.identifier.urlhttp://scitation.aip.org/content/aip/journal/apl/89/16/10.1063/1.2364459en
dc.language.isoenen
dc.publisherAIP Publishingen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectBiosensorsen
dc.titleLabel-free DNA sequence detection using oligonucleotide functionalized optical fiberen
dc.title.serialApplied Physics Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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