Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action

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dc.contributor.authorAilawadi, Shainaen
dc.contributor.authorKaelber, David C.en
dc.contributor.authorElangovan, Abbinayaen
dc.date.accessioned2025-07-25T13:12:08Zen
dc.date.available2025-07-25T13:12:08Zen
dc.date.issued2025-06-26en
dc.date.updated2025-07-25T13:08:53Zen
dc.description.abstractWhile the incidence of colorectal cancer (CRC) in patients above 50 years old has been decreasing over the last several decades, the incidence of CRC among younger patients has been increasing. Early-onset CRC (EO-CRC) is known to exhibit distinct characteristics including specific genetic mutations and modifiable risk factors, which warrants tailored screening and management approaches. This review synthesizes current insights on EO-CRC’s epidemiological, genetic, molecular, and clinical features, as well as a call for action for future research on prevention and clinical management.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAilawadi, S.; Kaelber, D.C.; Elangovan, A. Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action. Biomedicines 2025, 13, 1572.en
dc.identifier.doihttps://doi.org/10.3390/biomedicines13071572en
dc.identifier.urihttps://hdl.handle.net/10919/136904en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectearly-onset colorectal canceren
dc.subjectcolorectal canceren
dc.subjectepidemiologyen
dc.subjectmicrosatellite instabilityen
dc.subjectmodifiable risk factorsen
dc.titleEarly-Onset Colorectal Cancer: A Review of Current Insights and a Call for Actionen
dc.title.serialBiomedicinesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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