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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

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dc.contributor.authorFreed, Catherine P.en
dc.contributor.authorAdepoju, Olusegunen
dc.contributor.authorGillaspy, Glenda E.en
dc.contributor.departmentBiochemistryen
dc.date.accessioned2020-01-24T17:16:01Zen
dc.date.available2020-01-24T17:16:01Zen
dc.date.issued2020-01-17en
dc.date.updated2020-01-23T22:01:18Zen
dc.description.abstractInositol pyrophosphates (PP-InsPs) are an emerging class of &ldquo;high-energy&rdquo; intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling, and inositol hexakisphosphate (InsP<sub>6</sub>) storage in plants. While information regarding this new class of signaling molecules in plants is scarce, the enzymes responsible for their synthesis have recently been elucidated. This review focuses on InsP<sub>6</sub> synthesis and its conversion into PP-InsPs, containing seven and eight phosphate groups (InsP<sub>7</sub> and InsP<sub>8</sub>). These steps involve two types of enzymes: the ITPKs that phosphorylate InsP<sub>6</sub> to InsP<sub>7</sub>, and the PPIP5Ks that phosphorylate InsP<sub>7</sub> to InsP<sub>8</sub>. This review also considers the potential roles of PP-InsPs in plant hormone and inorganic phosphate (P<i>i</i>) signaling, along with an emerging role in bioenergetic homeostasis. PP-InsP synthesis and signaling are important for plant breeders to consider when developing strategies that reduce InsP<sub>6</sub> in plants, as this will likely also reduce PP-InsPs. Thus, this review is primarily intended to bridge the gap between the basic science aspects of PP-InsP synthesis/signaling and breeding/engineering strategies to fortify foods by reducing InsP<sub>6</sub>.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFreed, C.; Adepoju, O.; Gillaspy, G. Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?Plants 2020, 9, 115.en
dc.identifier.doihttps://doi.org/10.3390/plants9010115en
dc.identifier.urihttp://hdl.handle.net/10919/96576en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectinositolen
dc.subjectinositol phosphateen
dc.subjectinositol pyrophosphateen
dc.subjectinositol phosphate signalingen
dc.subjectinositol phosphate kinasesen
dc.subjectPPIP5Ken
dc.subjectITPKen
dc.subjectphytateen
dc.titleCan Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?en
dc.title.serialPlantsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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