Expanding Host Range and Cross-Species Infection of Hepatitis E Virus
dc.contributor.author | Meng, Xiang-Jin | en |
dc.date.accessioned | 2018-12-04T18:42:14Z | en |
dc.date.available | 2018-12-04T18:42:14Z | en |
dc.date.issued | 2016-08-04 | en |
dc.description.abstract | Hepatitis E is an important public health disease [1]. Although the mortality rate is less than 1% in the general population, it can reach up to 25% in infected pregnant women. According to the World Health Organization, each year an estimated 20 million infections occur worldwide resulting in >3 million symptomatic cases and 56,600 hepatitis E-related deaths (http://www.who.int/mediacentre/factsheets/fs280/en/). Large explosive waterborne outbreaks of hepatitis E are generally seen in developing countries with poor sanitation conditions, whereas in industrialized countries, sporadic and cluster cases of hepatitis E have been reported. Hepatitis E is a self-limiting acute disease that normally does not go into chronicity. However, recently, chronic hepatitis E has become a significant clinical problem in immunocompromised individuals such as organ transplant recipients [2]. The discovery of animal strains of hepatitis E virus (HEV) [3] that infect across species barriers revolutionizes the way we used to think about this important disease. Hepatitis E is now recognized as a zoonotic disease, and animal reservoirs exist [4]. Herein, I briefly discuss the ever-expanding host ranges, cross-species infection, zoonotic risk, and food safety of HEV. | en |
dc.description.sponsorship | The author's research on HEV is supported by the National Institutes of Health (R01AI074667 and R01AI050611). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en |
dc.format.extent | 6 pages | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.doi | https://doi.org/10.1371/journal.ppat.1005695 | en |
dc.identifier.eissn | 1553-7374 | en |
dc.identifier.issn | 1553-7366 | en |
dc.identifier.issue | 8 | en |
dc.identifier.other | e1005695 | en |
dc.identifier.pmid | 27490119 | en |
dc.identifier.uri | http://hdl.handle.net/10919/86218 | en |
dc.identifier.volume | 12 | en |
dc.language.iso | en | en |
dc.publisher | PLOS | en |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | zoonotic transmission | en |
dc.subject | family hepeviridae | en |
dc.subject | swine | en |
dc.subject | prevalence | en |
dc.subject | liver | en |
dc.subject | humans | en |
dc.subject | risk | en |
dc.subject | food | en |
dc.title | Expanding Host Range and Cross-Species Infection of Hepatitis E Virus | en |
dc.title.serial | PLOS Pathogens | en |
dc.type | Article - Refereed | en |
dc.type.dcmitype | Text | en |
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