Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

dc.contributor.authorMeng, Xiang-Jinen
dc.date.accessioned2018-12-04T18:42:14Zen
dc.date.available2018-12-04T18:42:14Zen
dc.date.issued2016-08-04en
dc.description.abstractHepatitis E is an important public health disease [1]. Although the mortality rate is less than 1% in the general population, it can reach up to 25% in infected pregnant women. According to the World Health Organization, each year an estimated 20 million infections occur worldwide resulting in >3 million symptomatic cases and 56,600 hepatitis E-related deaths (http://www.who.int/mediacentre/factsheets/fs280/en/). Large explosive waterborne outbreaks of hepatitis E are generally seen in developing countries with poor sanitation conditions, whereas in industrialized countries, sporadic and cluster cases of hepatitis E have been reported. Hepatitis E is a self-limiting acute disease that normally does not go into chronicity. However, recently, chronic hepatitis E has become a significant clinical problem in immunocompromised individuals such as organ transplant recipients [2]. The discovery of animal strains of hepatitis E virus (HEV) [3] that infect across species barriers revolutionizes the way we used to think about this important disease. Hepatitis E is now recognized as a zoonotic disease, and animal reservoirs exist [4]. Herein, I briefly discuss the ever-expanding host ranges, cross-species infection, zoonotic risk, and food safety of HEV.en
dc.description.sponsorshipThe author's research on HEV is supported by the National Institutes of Health (R01AI074667 and R01AI050611). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent6 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1005695en
dc.identifier.eissn1553-7374en
dc.identifier.issn1553-7366en
dc.identifier.issue8en
dc.identifier.othere1005695en
dc.identifier.pmid27490119en
dc.identifier.urihttp://hdl.handle.net/10919/86218en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectzoonotic transmissionen
dc.subjectfamily hepeviridaeen
dc.subjectswineen
dc.subjectprevalenceen
dc.subjectliveren
dc.subjecthumansen
dc.subjectrisken
dc.subjectfooden
dc.titleExpanding Host Range and Cross-Species Infection of Hepatitis E Virusen
dc.title.serialPLOS Pathogensen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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