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Determination of the activity of diclazuril against Sarcocystis neurona and Sarcocystis falcatula in cell cultures

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dc.contributor.authorLindsay, David S.en
dc.contributor.authorDubey, Jitender P.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:11Zen
dc.date.available2014-06-20T14:13:11Zen
dc.date.issued2000-02en
dc.description.abstractDiclazuril is a benzeneacetonitril anticoccidial that has excellent activity against the extraintestinal stages of Toxoplasma gondii and Neospora caninum. It also is highly active against intestinal coccidia of poultry. The present study examined the efficacy of diclazuril in inhibiting merozoite production of Sarcocystis neurona and Sarcocystis falcatula in bovine turbinate cell cultures. Diclazuril inhibited merozoite production by more than 80% in cultures of S. neurona or S.falcatula treated with 0.1 ng/ml diclazuril and greater than 95% inhibition of merozoite production was observed when infected cultures were treated with 1.0 ng/ml diclazuril. Diclazuril may have promise as a therapeutic agent in the treatment of S. neurona-induced equine protozoal myeloencephalitis in horses and S. falcatula infections in birds.en
dc.description.sponsorshipEquine Health Research Fund of the American Horse Shows Associationen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDavid S. Lindsay and J. P. Dubey (2000). "Determination of the Activity of Diclazuril Against Sarcocystis neurona and Sarcocystis falcatula in Cell Cultures," Journal of Parasitology, Vol. 86, No. 1, pp. 164-166. doi: http://dx.doi.org/10.1645/0022-3395(2000)086[0164:DOTAOD]2.0.CO;2en
dc.identifier.doihttps://doi.org/10.1645/0022-3395(2000)086[0164:dotaod]2.0.co;2en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49035en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/0022-3395%282000%29086%5B0164%3ADOTAOD%5D2.0.CO%3B2en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectequine protozoal myeloencephalitisen
dc.subjecttoxoplasma-gondiien
dc.subjectanticoccidialen
dc.subjectefficacyen
dc.subjectpsittacine birdsen
dc.subjecthorsesen
dc.subjectmiceen
dc.subjectencephalomyelitisen
dc.subjectseroprevalenceen
dc.subjectantibodiesen
dc.subjectopossumsen
dc.subjectparasitologyen
dc.titleDetermination of the activity of diclazuril against Sarcocystis neurona and Sarcocystis falcatula in cell culturesen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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