Recent Progress in Lyme Disease and Remaining Challenges

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dc.contributor.authorBobe, Jason R.en
dc.contributor.authorJutras, Brandon L.en
dc.contributor.authorHorn, Elizabeth J.en
dc.contributor.authorEmbers, Monica E.en
dc.contributor.authorBailey, Allisonen
dc.contributor.authorMoritz, Robert L.en
dc.contributor.authorZhang, Yingen
dc.contributor.authorSoloski, Mark J.en
dc.contributor.authorOstfeld, Richard S.en
dc.contributor.authorMarconi, Richard T.en
dc.contributor.authorAucott, Johnen
dc.contributor.authorMa'ayan, Avien
dc.contributor.authorKeesing, Feliciaen
dc.contributor.authorLewis, Kimen
dc.contributor.authorBen Mamoun, Choukrien
dc.contributor.authorRebman, Alison W.en
dc.contributor.authorMcClune, Mecaila E.en
dc.contributor.authorBreitschwerdt, Edward B.en
dc.contributor.authorReddy, Panga Jaipalen
dc.contributor.authorMaggi, Ricardoen
dc.contributor.authorYang, Franken
dc.contributor.authorNemser, Bennetten
dc.contributor.authorOzcan, Aydoganen
dc.contributor.authorGarner, Omaien
dc.contributor.authorDi Carlo, Dinoen
dc.contributor.authorBallard, Zacharyen
dc.contributor.authorJoung, Hyou-Armen
dc.contributor.authorGarcia-Romeu, Alberten
dc.contributor.authorGriffiths, Roland R.en
dc.contributor.authorBaumgarth, Nicoleen
dc.contributor.authorFallon, Brian A.en
dc.date.accessioned2022-01-16T19:52:49Zen
dc.date.available2022-01-16T19:52:49Zen
dc.date.issued2021-08-18en
dc.date.updated2022-01-16T19:52:45Zen
dc.description.abstractLyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.en
dc.description.versionPublished versionen
dc.format.extent25 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 666554 (Article number)en
dc.identifier.doihttps://doi.org/10.3389/fmed.2021.666554en
dc.identifier.eissn2296-858Xen
dc.identifier.issn2296-858Xen
dc.identifier.pmid34485323en
dc.identifier.urihttp://hdl.handle.net/10919/107683en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000692790200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectMedicine, General & Internalen
dc.subjectGeneral & Internal Medicineen
dc.subjectLyme diseaseen
dc.subjectpathogenesisen
dc.subjectdiagnosisen
dc.subjecttreatmenten
dc.subjectpreventionen
dc.subjectfield buildingen
dc.subjectPTLDen
dc.subjectvaccineen
dc.subjectBORRELIA-BURGDORFERI INFECTIONen
dc.subjectC-REACTIVE PROTEINen
dc.subjectWHITE-TAILED DEERen
dc.subjectB-CELL RESPONSESen
dc.subjectIXODES-SCAPULARISen
dc.subjectUNITED-STATESen
dc.subjectANTIBIOTIC-TREATMENTen
dc.subjectERYTHEMA MIGRANSen
dc.subjectMYCOBACTERIUM-TUBERCULOSISen
dc.subjectANAPLASMA-PHAGOCYTOPHILUMen
dc.titleRecent Progress in Lyme Disease and Remaining Challengesen
dc.title.serialFrontiers in Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2021-07-12en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistryen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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