Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus

dc.contributor.authorLi, S.en
dc.contributor.authorBrazhnik, P.en
dc.contributor.authorSobral, Brunoen
dc.contributor.authorTyson, John J.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2016-12-09T21:35:27Zen
dc.date.available2016-12-09T21:35:27Zen
dc.date.issued2009-08-01en
dc.description.abstractThe asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alphaproteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine (e.g., Rhizobium, Brucella).en
dc.description.sponsorshipThis research was supported by grants from the James S. McDonnell Foundation (21002050 to JJT), the National Science Foundation (DMS-0817314 and DMS-0342283 to PB), and the Virginia Bioinformatics Institute (BS). The funders had no role in study design, model development and analysis, decision to publish, or preparation of the manuscript.en
dc.description.versionPublished versionen
dc.format.extent? - ? (15) page(s)en
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1000463en
dc.identifier.issn1553-734Xen
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/73633en
dc.identifier.urlhttp://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000463en
dc.identifier.volume5en
dc.languageEnglishen
dc.publisherPLOSen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270799700026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiochemical Research Methodsen
dc.subjectMathematical & Computational Biologyen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectDEPENDENT POLAR LOCALIZATIONen
dc.subjectSIGNAL-TRANSDUCTION PROTEINen
dc.subjectXENOPUS-OOCYTE EXTRACTSen
dc.subjectM-PHASE CONTROLen
dc.subjectDNA-REPLICATIONen
dc.subjectESCHERICHIA-COLIen
dc.subjectCHROMOSOME-REPLICATIONen
dc.subjectHISTIDINE KINASEen
dc.subjectPARTITIONING PROTEINSen
dc.subjectORGANELLE DEVELOPMENTen
dc.titleTemporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentusen
dc.title.serialPLOS Computational Biologyen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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