Functional architecture of neural circuits for leg proprioception in Drosophila

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dc.contributor.authorChen, Chenghaoen
dc.contributor.authorAgrawal, Swetaen
dc.contributor.authorMark, Brandonen
dc.contributor.authorMamiya, Akiraen
dc.contributor.authorSustar, Anneen
dc.contributor.authorPhelps, Jasper S.en
dc.contributor.authorLee, Wei-Chung Allenen
dc.contributor.authorDickson, Barry J.en
dc.contributor.authorCard, Gwyneth M.en
dc.contributor.authorTuthill, John C.en
dc.date.accessioned2024-02-02T15:48:55Zen
dc.date.available2024-02-02T15:48:55Zen
dc.date.issued2021-10-11en
dc.description.abstractTo effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these diverse sensory signals are integrated by central proprioceptive circuits. We find that signals for leg joint position and directional movement converge in second-order neurons, revealing pathways for local feedback control of leg posture. Distinct populations of second-order neurons integrate tibia vibration signals across pairs of legs, suggesting a role in detecting external substrate vibration. In each pathway, the flow of sensory information is dynamically gated and sculpted by inhibition. Overall, our results reveal parallel pathways for processing of internal and external mechanosensory signals, which we propose mediate feedback control of leg movement and vibration sensing, respectively. The existence of a functional connectivity map also provides a resource for interpreting connectomic reconstruction of neural circuits for leg proprioception.en
dc.description.versionAccepted versionen
dc.format.extent21 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.cub.2021.09.035en
dc.identifier.eissn1879-0445en
dc.identifier.issn0960-9822en
dc.identifier.issue23en
dc.identifier.orcidAgrawal, Sweta [0000-0003-0547-4099]en
dc.identifier.otherS0960-9822(21)01275-6 (PII)en
dc.identifier.pmid34637749en
dc.identifier.urihttps://hdl.handle.net/10919/117826en
dc.identifier.volume31en
dc.language.isoenen
dc.publisherCell Pressen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/34637749en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDrosophilaen
dc.subjectcalcium imagingen
dc.subjectmotor controlen
dc.subjectneural circuitsen
dc.subjectoptogeneticsen
dc.subjectproprioceptionen
dc.subjectventral nerve corden
dc.subject.meshAnimalsen
dc.subject.meshDrosophilaen
dc.subject.meshProprioceptionen
dc.subject.meshMovementen
dc.subject.meshSensory Receptor Cellsen
dc.titleFunctional architecture of neural circuits for leg proprioception in <i>Drosophila</i>en
dc.title.serialCurrent Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2021-09-15en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/School of Neuroscienceen

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