ATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey bees

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dc.contributor.authorO'Neal, Scott T.en
dc.contributor.authorSwale, Daniel R.en
dc.contributor.authorAnderson, Troy D.en
dc.contributor.departmentEntomologyen
dc.date.accessioned2017-11-13T19:43:19Zen
dc.date.available2017-11-13T19:43:19Zen
dc.date.issued2017-08-17en
dc.description.abstractHoney bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world. Viral infections are thought to be a significant factor contributing to these declines, but viruses have proven a challenging pathogen to study in a bee model and interactions between viruses and the bee antiviral immune response remain poorly understood. In the work described here, we have demonstrated the use of flock house virus (FHV) as a model system for virus infection in bees and revealed an important role for the regulation of the bee antiviral immune response by ATP-sensitive inwardly rectifying potassium (KATP) channels. We have shown that treatment with the KATP channel agonist pinacidil increases survival of bees while decreasing viral replication following infection with FHV, whereas treatment with the KATP channel antagonist tolbutamide decreases survival and increases viral replication. Our results suggest that KATP channels provide a significant link between cellular metabolism and the antiviral immune response in bees.en
dc.description.sponsorshipThis material is based upon work that is supported by the National Institute of Food and Agriculture, United States Department of Agriculture, under award number 2017-67011- 26048.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-017-09448-yen
dc.identifier.urihttp://hdl.handle.net/10919/80363en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherNatureen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleATP-sensitive inwardly rectifying potassium channel regulation of viral infections in honey beesen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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