Natural Stressors, Posttraumatic Stress Disorder, and Wound Healing, in a Murine Model

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dc.contributor.authorParker, Jason Lloyden
dc.contributor.committeechairHarrison, David W.en
dc.contributor.committeememberBell, Martha Annen
dc.contributor.committeememberHoffman, Kurt A.en
dc.contributor.committeememberJones, Russell T.en
dc.contributor.departmentPsychologyen
dc.date.accessioned2017-04-06T15:45:23Zen
dc.date.adate2010-06-11en
dc.date.available2017-04-06T15:45:23Zen
dc.date.issued2010-03-03en
dc.date.rdate2016-10-17en
dc.date.sdate2010-04-14en
dc.description.abstractThis study investigated the use of "naturalistic stressors" such as physical restraint and animal pheromones on the etiology of Posttraumatic Stress Disorder in a murine model. Pilot data suggest that stress effects may lead to an increase in the amount of time needed for cutaneous wounds to heal. Pilot data to support the creation of this model are presented suggesting that a delayed stress response may inhibit healing rates. In the present study an animal model of PTSD was used to investigate the effect of stress on the immune system. Yehuda and Antelman's (1993) nonhuman animal model of Posttraumatic Stress Disorder was tested with respect to the animals' immune response to cutaneous wounding. Additionally, effects of stress on exploratory behavior and activity were examined. The findings support the hypothesis that restraint and pheremonal stress and housing arrangements influence the ability of mice to heal a 1.5 mm punch biopsy, and exploratory behavior. The findings also support a profile for the Post-Traumatic Mouse.en
dc.description.degreePh. D.en
dc.identifier.otheretd-04142010-160829en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04142010-160829/en
dc.identifier.urihttp://hdl.handle.net/10919/77370en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectWound Healingen
dc.subjectAwesomenessen
dc.subjectAnimal Modelsen
dc.subjectPosttraumatic Stressen
dc.titleNatural Stressors, Posttraumatic Stress Disorder, and Wound Healing, in a Murine Modelen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplinePsychologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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