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Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model

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dc.contributor.authorEl-Kadi, Samer Wassimen
dc.contributor.authorBoutry, Claireen
dc.contributor.authorSuryawan, Agusen
dc.contributor.authorGazzaneo, Maria C.en
dc.contributor.authorOrellana, Renan A.en
dc.contributor.authorSrivastava, Neerajen
dc.contributor.authorNguyen, Hanh V.en
dc.contributor.authorKimball, Scot R.en
dc.contributor.authorFiorotto, Marta L.en
dc.contributor.authorDavis, Teresa A.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2020-03-10T13:52:55Zen
dc.date.available2020-03-10T13:52:55Zen
dc.date.issued2018-10en
dc.description.abstractBackground: Orogastric tube feeding is indicated in neonates with an impaired ability to ingest food normally and can be administered with an intermittent bolus or continuous feeding schedule. Objectives: The objectives were to 1) compare the long-term effect of continuous with intermittent feeding on growth using the newborn pig as a model, 2) determine whether feeding frequency alters lean tissue and fat mass gain, and 3) identify the signaling mechanisms by which protein deposition is controlled in skeletal muscle in response to feeding frequency. Design: Neonatal pigs were fed the same amount of a balanced formula by orogastric tube either as an intermittent bolus meal every 4 h (INT) or as a continuous infusion (CON). Body composition was assessed at the start and end of the study by dual-energy X-ray absorptiometry, and hormone and substrate profiles, muscle mass, protein synthesis, and indexes of nutrient and insulin signaling were measured after 21 d. Results: Body weight, lean mass, spine length, and skeletal muscle mass were greater in the INT group than in the CON group. Skeletal muscle fractional protein synthesis rates were greater in the INT group after a meal than in the CON group and were associated with higher circulating branched-chain amino acid and insulin concentrations. Skeletal muscle protein kinase B (PKB) and ribosomal protein S6 kinase phosphorylation and eukaryotic initiation factor (eIF) 4E-eIF4G complex formation were higher, whereas eIF2 alpha phosphorylation was lower in the INT group than in the CON group, indicating enhanced activation of insulin and amino acid signaling to translation initiation. Conclusions: These results suggest that when neonates are fed the same amounts of nutrients as intermittent meals rather than continuously there is greater lean growth. This response can be ascribed, in part, to the pulsatile pattern of amino acids, insulin, or both induced by INT, which enables the responsiveness of anabolic pathways to feeding to be sustained chronically in skeletal muscle.en
dc.description.adminPublic domain – authored by a U.S. government employeeen
dc.description.notesSupported by National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR044474 (TAD) and AR46308 (MLF), National Institute of Child Health and Human Development grants HD072891 (TAD) and HD085573 (TAD), USDA National Institute of Agriculture grant 2013-67015-20438 (TAD), and by the USDA-Agricultural Research Service under cooperative agreement 6250-510000-055 (TAD).en
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases grants [AR044474, AR46308]; National Institute of Child Health and Human Development grants [HD072891, HD085573]; USDA National Institute of Agriculture grant [2013-67015-20438]; USDA-Agricultural Research ServiceUnited States Department of Agriculture (USDA) [6250-510000-055]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/ajcn/nqy133en
dc.identifier.eissn1938-3207en
dc.identifier.issn0002-9165en
dc.identifier.issue4en
dc.identifier.pmid30239549en
dc.identifier.urihttp://hdl.handle.net/10919/97282en
dc.identifier.volume108en
dc.language.isoenen
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectinfanten
dc.subjectbody compositionen
dc.subjectskeletal muscleen
dc.subjectgrowthen
dc.subjectprotein synthesisen
dc.titleIntermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet modelen
dc.title.serialAmerican Journal of Clinical Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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