Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala

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dc.contributor.authorJarome, Timothy J.en
dc.contributor.authorWerner, Craig T.en
dc.contributor.authorKwapis, Janine L.en
dc.contributor.authorHelmstetter, Fred J.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2018-11-19T18:32:06Zen
dc.date.available2018-11-19T18:32:06Zen
dc.date.issued2011-09en
dc.description.abstractProtein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown. Here we provide the first evidence that protein degradation through the UPS is critically engaged at amygdala synapses during memory formation and retrieval. Fear conditioning results in NMDA-dependent increases in degradationspecific polyubiquitination in the amygdala, targeting proteins involved in translational control and synaptic structure and blocking the degradation of these proteins significantly impairs long-term memory. Furthermore, retrieval of fear memory results in a second wave of NMDA-dependent polyubiquitination that targets proteins involved in translational silencing and synaptic structure and is critical for memory updating following recall. These results indicate that UPS-mediated protein degradation is a major regulator of synaptic plasticity necessary for the formation and stability of long-term memories at amygdala synapses.en
dc.description.sponsorshipNational Institutes of Healthen
dc.description.sponsorshipNIH: R01-MH069558en
dc.description.sponsorshipNIH: F31-MH088125en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0024349en
dc.identifier.issue9en
dc.identifier.urihttp://hdl.handle.net/10919/85890en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleActivity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdalaen
dc.title.serialPLOS Oneen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, School of Animal Sciences