More Than a Small Brain: The Importance of Studying Neural Function during Development

Simple item page
dc.contributor.authorDooley, James C.en
dc.contributor.authorvan der Heijden, Meike E.en
dc.date.accessioned2024-12-02T15:15:17Zen
dc.date.available2024-12-02T15:15:17Zen
dc.date.issued2024-11-27en
dc.description.abstractThe nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of "developmental systems neuroscience" combines the molecular and genetic perspectives of developmental neuroscience with the (typically adult-focused) functional perspective of systems neuroscience. This combination of approaches is critical to understanding how a handful of cells eventually produce the wide range of behaviors necessary for survival. Functional circuit development typically lags behind neural connectivity, leading to intermediate stages of neural activity that are either not seen in adults or, if present, are considered pathophysiological. Developmental systems neuroscience examines these intermediate stages of neural activity, mapping out the critical phases and inflection points of neural circuit function to understand how neural activity and behavior emerge across development. Beyond understanding typical development, this approach provides invaluable insight into the pathophysiology of neurodevelopmental disorders by identifying when and how functional development diverges between health and disease. We argue that developmental systems neuroscience will identify important periods of neural development, reveal novel therapeutic windows for treatment, and set the stage to answer fundamental questions about the brain in health and disease.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.1367-24.2024en
dc.identifier.eissn1529-2401en
dc.identifier.issn0270-6474en
dc.identifier.issue48en
dc.identifier.orcidvan der Heijden, Meike [0000-0003-0801-8806]en
dc.identifier.otherPMC11604142en
dc.identifier.other44/48/e1367242024 (PII)en
dc.identifier.urihttps://hdl.handle.net/10919/123671en
dc.identifier.volume44en
dc.language.isoenen
dc.publisherSociety for Neuroscienceen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/39603806en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcerebellumen
dc.subjectdevelopmenten
dc.subjectmotor systemsen
dc.subjectneurodevelopmental disordersen
dc.subjectsensory systemsen
dc.subject.meshHumansen
dc.subject.meshAnimalsen
dc.subject.meshBrainen
dc.subject.meshNeurosciencesen
dc.subject.meshNerve Neten
dc.subject.meshNeuronsen
dc.subject.meshNeurodevelopmental Disordersen
dc.titleMore Than a Small Brain: The Importance of Studying Neural Function during Developmenten
dc.title.serialJournal of Neuroscienceen
dc.typeArticleen
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2024-10-17en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/School of Neuroscienceen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dooley & Van der Heijden, 2024 - JNeuro.pdf
Size:
733.06 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Plain Text
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, School of Neuroscience