Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04

dc.contributor.authorAlmeida, Celsoen
dc.contributor.authorBills, Geralden
dc.contributor.authorGonzález-Menéndez, Víctoren
dc.contributor.authorMartin, Jesúsen
dc.contributor.authorTormo, José R.en
dc.contributor.authorGenilloud, Olgaen
dc.date.accessioned2017-09-20T18:35:49Zen
dc.date.available2017-09-20T18:35:49Zen
dc.date.issued2017-09-05en
dc.date.updated2017-09-20T18:35:50Zen
dc.description.abstractPrevious investigations of the sponge-derived fungus <i>Stachylidium bicolor (S. bicolor) </i>293K04 led to the isolation of the biosynthetically unusual polyketides marilines A-C and the bioactive tetrapeptides endolides A-B, identified as potential neuropathic drug leads. Furthermore, prior extended solid cultivation of <i>S. bicolor </i>293K04 for 60 days resulted in a significant increase of polyketide yield, and the isolation of seven new polyketides. Due to the interest in endolide activity, unusual biosynthetic diversity, and the late stage polyketide production, we studied the cultivation conditions for determining the production time distribution and yields of these secondary metabolites. Results indicated a first production phase of secondary metabolite dominated by peptides, after 21–23 days. Polyketide mariline A1/A2 only started at day 35 of growth, an unusually late period for secondary metabolite expression. This unusual bimodal sequential expression of different families of secondary metabolites suggests value in exploring extended cultivation times to identify novel bioactive fungal compounds.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlmeida, C.; Bills, G.; González-Menéndez, V.; Martin, J.; Tormo, J.R.; Genilloud, O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3, 45.en
dc.identifier.doihttps://doi.org/10.3390/fermentation3030045en
dc.identifier.urihttp://hdl.handle.net/10919/79356en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectfungien
dc.subjectnatural productsen
dc.subjectfermentationen
dc.subjectproduction conditionsen
dc.titleTime-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04en
dc.title.serialFermentationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
fermentation-03-00045-v2.pdf
Size:
2.99 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description: