Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA

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dc.contributor.authorWynn, Jessica E.en
dc.contributor.authorZhang, Wenyuen
dc.contributor.authorTebit, Denis M.en
dc.contributor.authorGray, Laurie R.en
dc.contributor.authorHammarskjold, Marie-Louiseen
dc.contributor.authorRekosh, Daviden
dc.contributor.authorSantos, Webster L.en
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.date.accessioned2017-05-01T06:42:18Zen
dc.date.available2017-05-01T06:42:18Zen
dc.date.issued2016-06-06en
dc.description.abstractHigh throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.en
dc.format.extent1436-1440en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifierc6md00171h.pdfen
dc.identifierc6md00171h1.pdfen
dc.identifierc6md00171h2.zipen
dc.identifier.doihttps://doi.org/10.1039/c6md00171hen
dc.identifier.eissn2040-2511en
dc.identifier.issn2040-2503en
dc.identifier.issue7en
dc.identifier.urihttp://hdl.handle.net/10919/77562en
dc.identifier.volume7en
dc.language.isoen_USen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofRoyal Society of Chemistry Gold Open Access - 2016en
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.holderWynn, Jessica E.en
dc.rights.holderZhang, Wenyuen
dc.rights.holderTebit, Denis M.en
dc.rights.holderGray, Laurie R.en
dc.rights.holderHammarskjold, Marie-Louiseen
dc.rights.holderRekosh, Daviden
dc.rights.holderSantos, Webster L.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleEffect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNAen
dc.title.serialMedicinal Chemical Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeDataseten

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