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Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation

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dc.contributor.authorMartin, Kileyen
dc.contributor.authorMusaus, Madelineen
dc.contributor.authorNavabpour, Shaghayeghen
dc.contributor.authorGustin, Aspenen
dc.contributor.authorRay, W. Keithen
dc.contributor.authorHelm, Richard F.en
dc.contributor.authorJarome, Timothy J.en
dc.date.accessioned2022-04-06T12:17:43Zen
dc.date.available2022-04-06T12:17:43Zen
dc.date.issued2021-08en
dc.description.abstractStrong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the latter of which occurred at chaperones or RNA processing proteins. In vivo CRISPR-dCas9-mediated repression of protein degradation in the dorsal hippocampus impaired contextual fear memory in females, but not males. These results suggest a sex-specific role for protein degradation in the hippocampus during the consolidation of a contextual fear memory.en
dc.description.notesThis work was supported by National Institutes of Health (NIH) grants MH120498, MH120569, MH122414, and MH123742 (to T.J.J.).en
dc.description.sponsorshipNational Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [MH120498, MH120569, MH122414, MH123742]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1101/lm.053429.121en
dc.identifier.eissn1549-5485en
dc.identifier.issn1072-0502en
dc.identifier.issue8en
dc.identifier.pmid34266989en
dc.identifier.urihttp://hdl.handle.net/10919/109569en
dc.identifier.volume28en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.titleFemales, but not males, require protein degradation in the hippocampus for contextual fear memory formationen
dc.title.serialLearning & Memoryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, School of Animal Sciences
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Biochemistry
Scholarly Works, Fralin Biomedical Research Institute at VTC
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