Hybrid Spectral Micro-CT: System Implementation, Exposure Reduction, K-edge Imaging Optimization, and Content Management
| dc.contributor.author | Bennett, James | en |
| dc.contributor.committeechair | Cao, Guohua | en |
| dc.contributor.committeechair | Wang, Ge | en |
| dc.contributor.committeemember | Rylander, Christopher G. | en |
| dc.contributor.committeemember | Butler, Anthony | en |
| dc.contributor.committeemember | Yu, Hengyong | en |
| dc.contributor.department | Biomedical Engineering | en |
| dc.date.accessioned | 2014-02-22T09:00:14Z | en |
| dc.date.available | 2014-02-22T09:00:14Z | en |
| dc.date.issued | 2014-02-21 | en |
| dc.description.abstract | Spectral computed tomography (CT) has proven an important development in biomedical imaging, yet there are several limitations to this nascent technology. Near-term implementation of spectral CT imaging can be enhanced using a hybrid architecture that integrates a narrow-beam spectral 'interior' imaging chain integrated with a traditional wide-beam 'global' imaging chain. The first study demonstrates the feasibility of hybrid spectral micro-CT architecture with a first-of-its-kind system implementation and preliminary results showing improved contrast resolution and spatial resolution. The second study seeks to characterize the hybrid spectral micro-CT scan protocol for reduction of radiation exposure. In the third study, the spectral 'interior' imaging chain was optimized for K-edge imaging of high-z elemental contrast agents. In the final study, an open-source, low-cost solution for managing digital content in an academic setting was demonstrated. The results of these studies confirm the merits of a hybrid architecture and warrant further consideration in future pre-clinical and clinical spectral micro-CT and CT scanner design and protocols. | en |
| dc.description.degree | Ph. D. | en |
| dc.format.medium | ETD | en |
| dc.identifier.other | vt_gsexam:2258 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/25525 | en |
| dc.publisher | Virginia Tech | en |
| dc.rights | In Copyright | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
| dc.subject | Micro-CT | en |
| dc.subject | Spectral CT | en |
| dc.subject | Hybrid Imaging | en |
| dc.subject | K-edge Imaging | en |
| dc.subject | Content Management | en |
| dc.title | Hybrid Spectral Micro-CT: System Implementation, Exposure Reduction, K-edge Imaging Optimization, and Content Management | en |
| dc.type | Dissertation | en |
| thesis.degree.discipline | Biomedical Engineering | en |
| thesis.degree.grantor | Virginia Polytechnic Institute and State University | en |
| thesis.degree.level | doctoral | en |
| thesis.degree.name | Ph. D. | en |