Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications

dc.contributor.authorMartínez, Estefaníaen
dc.contributor.authorGamboa, Jenniferen
dc.contributor.authorFinkielstein, Carla V.en
dc.contributor.authorCañas, Ana I.en
dc.contributor.authorOsorio, Marlon A.en
dc.contributor.authorVélez, Yesiden
dc.contributor.authorLlinas, Néstoren
dc.contributor.authorCastro, Cristina I.en
dc.date.accessioned2025-03-10T14:42:03Zen
dc.date.available2025-03-10T14:42:03Zen
dc.date.issued2025-03-05en
dc.date.updated2025-03-09T04:19:56Zen
dc.description.abstractOral drug administration is the preferred route for pharmaceuticals, accounting for ~90% of the global pharmaceutical market due to its convenience and cost-effectiveness. This study provides a comprehensive scientific and technological analysis of the latest advances in oral dosage forms for colon-targeted drug delivery. Utilizing scientific and patent databases, along with a bibliometric analysis and bibliographical review, we compared the oral dosage forms (technology) with the specific application of the technology (colon delivery) using four search equations. Our findings reveal a gap in the publications and inventions associated with oral dosage forms for colon release compared to oral dosage forms for general applications. While tablets and capsules were found the most used dosage forms, other platforms such as nanoparticles, microparticles, and emulsions have been also explored. Enteric coatings are the most frequently applied excipient to prevent the early drug release in the stomach with pH-triggered systems being the predominant release mechanism. In summary, this review provides a comprehensive analysis of the last advancements and high-impact resources in the development of oral dosage forms for colon-targeted drug delivery, providing insights into the technological maturity of these approaches.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJournal of Materials Science: Materials in Medicine. 2025 Mar 05;36(1):24en
dc.identifier.doihttps://doi.org/10.1007/s10856-025-06868-5en
dc.identifier.urihttps://hdl.handle.net/10919/124832en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleOral dosage forms for drug delivery to the colon: an existing gap between research and commercial applicationsen
dc.title.serialJournal of Materials Science: Materials in Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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