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Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring

dc.contributor.authorda Cruz, Raquel S.en
dc.contributor.authorCarney, Elissa J.en
dc.contributor.authorClarke, Johanen
dc.contributor.authorCao, Hongen
dc.contributor.authorCruz, M. Idaliaen
dc.contributor.authorBenitez, Carlosen
dc.contributor.authorJin, Luen
dc.contributor.authorFu, Yien
dc.contributor.authorCheng, Zuolinen
dc.contributor.authorWang, Yueen
dc.contributor.authorde Assis, Soniaen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2018-09-04T12:52:15Zen
dc.date.available2018-09-04T12:52:15Zen
dc.date.issued2018-08-30en
dc.date.updated2018-09-02T03:19:09Zen
dc.description.abstractBackground While many studies have shown that maternal factors in pregnancy affect the cancer risk for offspring, few studies have investigated the impact of paternal exposures on their progeny’s risk of this disease. Population studies generally show a U-shaped association between birthweight and breast cancer risk, with both high and low birthweight increasing the risk compared with average birthweight. Here, we investigated whether paternal malnutrition would modulate the birthweight and later breast cancer risk of daughters. Methods Male mice were fed AIN93G-based diets containing either 17.7% (control) or 8.9% (low-protein (LP)) energy from protein from 3 to 10 weeks of age. Males on either group were mated to females raised on a control diet. Female offspring from control and LP fathers were treated with 7,12-dimethylbenz[a]anthracene (DMBA) to initiate mammary carcinogenesis. Mature sperm from fathers and mammary tissue and tumors from female offspring were used for epigenetic and other molecular analyses. Results We found that paternal malnutrition reduces the birthweight of daughters and leads to epigenetic and metabolic reprogramming of their mammary tissue and tumors. Daughters of LP fathers have higher rates of mammary cancer, with tumors arising earlier and growing faster than in controls. The energy sensor, the AMP-activated protein kinase (AMPK) pathway, is suppressed in both mammary glands and tumors of LP daughters, with consequent activation of mammalian target of rapamycin (mTOR) signaling. Furthermore, LP mammary tumors show altered amino-acid metabolism with increased glutamine utilization. These changes are linked to alterations in noncoding RNAs regulating those pathways in mammary glands and tumors. Importantly, we detect alterations in some of the same microRNAs/target genes found in our animal model in breast tumors of women from populations where low birthweight is prevalent. Conclusions Our study suggests that ancestral paternal malnutrition plays a role in programming offspring cancer risk and phenotype by likely providing a metabolic advantage to cancer cells.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBreast Cancer Research. 2018 Aug 30;20(1):99en
dc.identifier.doihttps://doi.org/10.1186/s13058-018-1034-7en
dc.identifier.urihttp://hdl.handle.net/10919/84950en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titlePaternal malnutrition programs breast cancer risk and tumor metabolism in offspringen
dc.title.serialBreast Cancer Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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