Association of MHCY genotypes in lines of chickens divergently selected for high or low antibody response to sheep red blood cells

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dc.contributor.authorZhang, Jibinen
dc.contributor.authorGoto, Ronald M.en
dc.contributor.authorHonaker, Christa F.en
dc.contributor.authorSiegel, Paul B.en
dc.contributor.authorTaylor, Robert L.en
dc.contributor.authorParmentier, Henk K.en
dc.contributor.authorMiller, Marcia M.en
dc.date.accessioned2022-07-21T15:02:16Zen
dc.date.available2022-07-21T15:02:16Zen
dc.date.issued2022-03en
dc.description.abstractThe chicken MHCY region contains members of several gene families including a family of highly polymorphic MHC class I genes that are structurally distinct from their classical class I gene counterparts. Genetic variability at MHCY could impart variability in immune responses, but robust tests for whether or not this occurs have been lacking. Here we defined the MHCY genotypes present in 2 sets of chicken lines selected for high or low antibody response, the Virginia Tech (VT) HAS and LAS, and the Wageningen University (WU) HA and LA lines. Both sets were developed under long-term bidirectional selection for differences in antibody responses following immunization with the experimental antigen sheep red blood cells. Lines in which selection was relaxed (VT HAR and LAR) or lacking (WU C) provided controls. We looked for evidence of association between MHCY genotypes and antibody titers. Chickens were typed for MHCY using a recently developed method based on a multilocus short tandem repeat sequence found across MHCY haplotypes. Five MHCY haplotypes were found segregating in the VT HAS and LAS lines. One haplotype was present only in HAS chickens, and another was present only in LAS chickens with distribution of the remaining 3 haplotypes differing significantly between the lines. In the WU HA and LA lines, there was a similar MHCY asymmetry. The control populations lacked similar asymmetries. These observations support the likelihood of MHCY genetics affecting heritable antibody responses and provide a basis for further investigations into the role of MHCY region genes in guiding immune responses in chickens.en
dc.description.notesThe authors acknowledge the excellent support for STR typing provided by Rosalina Lonergan in the City of Hope Integrated Genomics Core. This work was supported in part by the US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) National Research Initiative Competitive Grant Nos. 2017-67017-26570 and funds from a City of Hope donor.en
dc.description.sponsorshipRosalina Lonergan in the City of Hope Integrated Genomics Core; US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) National Research Initiative Competitive Grant [2017-67017-26570]; City of Hope donoren
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.psj.2021.101621en
dc.identifier.eissn1525-3171en
dc.identifier.issue3en
dc.identifier.other101621en
dc.identifier.pmid34995879en
dc.identifier.urihttp://hdl.handle.net/10919/111309en
dc.identifier.volume101en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMHCYen
dc.subjectheritable antibody responsesen
dc.subjectchickenen
dc.subjectVirginia Tech HAS and LASen
dc.subjectWageningen University HA and LAen
dc.titleAssociation of MHCY genotypes in lines of chickens divergently selected for high or low antibody response to sheep red blood cellsen
dc.title.serialPoultry Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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