The effect of dietary vitamin E on the humoral and cell-mediated immune response of pigs housed at different environmental temperatures or weaned at various ages

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dc.contributor.authorBonnette, Edward Dwainen
dc.contributor.committeecochairKornegay, E.T.en
dc.contributor.committeecochairLindemann, Merlin D.en
dc.contributor.committeememberBlodgett, Dennisen
dc.contributor.committeememberWood, Cindy M.en
dc.contributor.committeememberNotter, David R.en
dc.contributor.departmentAnimal Scienceen
dc.date.accessioned2019-03-26T19:52:59Zen
dc.date.available2019-03-26T19:52:59Zen
dc.date.issued1988en
dc.description.abstractA set of experiments were conducted to evaluate the antibody response, serum vitamin E level, cortisol concentration and performance of pigs weaned at three ages (21, 28 or 35 d) and fed diet containing either 11 or 220 IU/kg diet recommended level of vitamin E. Supplemental dietary vitamin E (220 IU) increased the concentration of serum vitamin E but, did not affect performance, cortisol concentrations or the antibody response. As weaning age increased, weekly performance increased linearly as did cortisol levels. Animals weaned at 35 d age had the largest primary antibody response, but this difference was not observed for the secondary response. A second set of experiments evaluated effects of four dietary vitamin E levels (11, 110, 220 and 550 IU/kg feed) on the humoral and cell-mediated immune response and performance of 4 wk old weanling pigs housed at one of two nursery temperatures (19 or 30°C). Performance was greater for pigs housed at 19°C compared with pigs housed at 30°C, but mitogen stimulation indices of white blood cells, plasma cortisol levels, and antibody titers were similar. Serum and liver vitamin E levels linearly increased with increasing dietary vitamin E level, but performance, cortisol, antibody levels and mitogen induced stimulation indexes were not affected by supplemental vitamin E levels. In the third experiment, sows fed a NRC level of vitamin E demonstrated little fluctuation in serum vitamin E concentration during a 5 wk lactation period. There was a high concentration of vitamin E in colostrum, followed by a sharp decrease in milk vitamin E concentration after the first week of lactation and remained constant for the next four weeks. Piglet serum was initially low in vitamin Eat 1 d of age but increased with time peaking about week 3. These experiments suggest that supplementing dietary vitamin E above the levels recommended by the NRC to baby pigs (which nursed sows fed NRC recommended levels of vitamin E) will not influence cell-mediated or humeral immune response, performance parameters or cortisol levels when pigs were weaned at various ages or exposed to environmental temperature changes.en
dc.description.degreeDoctor of Philosophyen
dc.format.extentxv, 168 leavesen
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/10919/88625en
dc.language.isoen_USen
dc.publisherVirginia Polytechnic Institute and State Universityen
dc.relation.isformatofOCLC# 19721694en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1988.B667en
dc.subject.lcshSwine -- Nutritionen
dc.subject.lcshVitamin E in animal nutritionen
dc.titleThe effect of dietary vitamin E on the humoral and cell-mediated immune response of pigs housed at different environmental temperatures or weaned at various agesen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.nameDoctor of Philosophyen

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