Sensing local energetics to acutely regulate mitophagy in skeletal muscle

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dc.contributor.authorNichenko, Anna S.en
dc.contributor.authorSpecht, Kalyn S.en
dc.contributor.authorCraige, Siobhan M.en
dc.contributor.authorDrake, Joshua C.en
dc.date.accessioned2023-02-20T17:53:24Zen
dc.date.available2023-02-20T17:53:24Zen
dc.date.issued2022-08-29en
dc.date.updated2023-02-20T15:08:04Zen
dc.description.abstractThe energetic requirements of skeletal muscle to sustain movement, as during exercise, is met largely by mitochondria, which form an intricate, interconnected reticulum. Maintenance of a healthy mitochondrial reticulum is essential for skeletal muscle function, suggesting quality control pathways are spatially governed. Mitophagy, the process by which damaged and/or dysfunctional regions of the mitochondrial reticulum are removed and degraded, has emerged as an integral part of the molecular response to exercise. Upregulation of mitophagy in response to acute exercise is directly connected to energetic sensing mechanisms through AMPK. In this review, we discuss the connection of mitophagy to muscle energetics and how AMPK may spatially control mitophagy through multiple potential means.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fcell.2022.987317en
dc.identifier.eissn2296-634Xen
dc.identifier.issn2296-634Xen
dc.identifier.orcidDrake, Joshua [0000-0001-6658-4975]en
dc.identifier.otherPMC9465048en
dc.identifier.other987317 (PII)en
dc.identifier.pmid36105350en
dc.identifier.urihttp://hdl.handle.net/10919/113877en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/36105350en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAMPKen
dc.subjectenergetic stressen
dc.subjectmitochondriaen
dc.subjectmitophagyen
dc.subjectreactive oxygen speciesen
dc.subject1 Underpinning researchen
dc.subject1.1 Normal biological development and functioningen
dc.subjectMusculoskeletalen
dc.titleSensing local energetics to acutely regulate mitophagy in skeletal muscleen
dc.title.serialFrontiers in Cell and Developmental Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2022-08-01en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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