Metabolic syndrome and risk factors for cardiovascular disease: are nonagenarians protected?

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dc.contributor.authorFrisard, Madlyn I.en
dc.contributor.authorRood, Jennifer C.en
dc.contributor.authorFang, Xiaobingen
dc.contributor.authorSu, Josephen
dc.contributor.authorWelsh, David A.en
dc.contributor.authorJazwinski, S. Michalen
dc.contributor.authorRavussin, Ericen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2016-11-17T20:55:57Zen
dc.date.available2016-11-17T20:55:57Zen
dc.date.issued2009-03-01en
dc.description.abstractThis study assessed cardiovascular disease risk factors in three groups of human subjects aged 20–34 [young, 20 male (M)/33 female (F)], 60–74 (aged, 29M/29F), and > 90 years (nonagenarian, 47M/50F). Components of the metabolic syndrome, cardiovascular disease, and markers of inflammation and oxidative stress were assessed. Nonagenarians weighed less than the two other groups (P < 0.001); however, there was no difference in percent fat among the three groups. Aged individuals had the highest prevalence of the metabolic syndrome (P < 0.001) according to the Adult Treatment Panel III classification. Both fibrinogen and homocysteine concentrations were significantly higher in the nonagenarians compared to younger groups. However, there were no significant differences between groups in fasting insulin, high sensitive C-reactive protein, and plasminogen activator inhibitor 1 concentrations. There were also no relationships between inflammation/ oxidative stress and the metabolic syndrome or cardiovascular disease although nonagenarians appear to be protected from oxidative damage to DNA.en
dc.description.versionPublished versionen
dc.format.extent67 - 75 (9) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1007/s11357-008-9082-zen
dc.identifier.issn0161-9152en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/73473en
dc.identifier.volume31en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofLouisiana Healthy Aging Studyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000263644800007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectGeosciences, Multidisciplinaryen
dc.subjectGeologyen
dc.subjectDISSOLVED ORGANIC-CARBONen
dc.subjectCATCHMENT-SCALEen
dc.subjectFOREST ECOSYSTEMSen
dc.subjectNORTHERN SWEDENen
dc.subjectRESIDENCE TIMEen
dc.subjectBOREAL STREAMSen
dc.subjectSOILen
dc.subjectRUNOFFen
dc.subjectMATTERen
dc.subjectEXPORTen
dc.titleMetabolic syndrome and risk factors for cardiovascular disease: are nonagenarians protected?en
dc.title.serialAgeen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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