Hypothalamic beta-endorphin, body weight, and food intake in ovarian steroid treated rats
| dc.contributor.author | Brown, Amy C. | en |
| dc.contributor.department | Human Nutrition and Foods | en |
| dc.date.accessioned | 2022-05-09T17:42:49Z | en |
| dc.date.available | 2022-05-09T17:42:49Z | en |
| dc.date.issued | 1986 | en |
| dc.description.abstract | To test the hypothesis that hypothalamic β-endorphin levels were related to the body weight changes occurring with ovarian steroid treatments, 80 adult female Sprague-Dawley rats were ovariectomized and allowed to recover for 7 days. Four treatment groups of 20 each were subjected to daily injections for 14 days with A) oil, B) β-estradiol benzoate (2µg), C) β-estradiol benzoate (2µg) plus progesterone (5mg), or D) progesterone (5mg). Weight gain was significantly (p < 0.01) lower in the estrogen group when compared to the control, estrogen/progesterone, or progesterone groups. The estrogen/progesterone-treated group gained significantly less weight than either the control or progesterone group. A significant (p < 0.05) decrease in food intake was also observed in the estrogen and estrogen/progesterone groups when compared to the control and progesterone groups, but not between each other. The progesterone-treated group was not significantly different from the controls in either weight gain or food intake. Hypothalamic β-endorphin (ng/mg protein) concentrations were significantly (p < 0.05) higher in the estrogen- and estrogen/progesterone-treated groups compared to the control and progesterone groups. Again, much like the weight gain, food intake, and hypothalamic β-endorphin (ng/mg protein), the estrogen and estrogen/progesterone groups had significantly (p < 0.05) heavier adrenal weights when compared to the controls and progesterone groups. There was no significant difference in plasma corticosterone levels between any of the groups. In this study, hypothalamic β-endorphin (ng/mg protein) appeared to be effected by ovarian steroid hormone treatment. Whether this is related to the weight gain also observed with the treatments remains to be determined. | en |
| dc.description.degree | Ph. D. | en |
| dc.format.extent | ix, 150 leaves | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.uri | http://hdl.handle.net/10919/109942 | en |
| dc.language.iso | en | en |
| dc.publisher | Virginia Polytechnic Institute and State University | en |
| dc.relation.isformatof | OCLC# 15233939 | en |
| dc.rights | In Copyright | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
| dc.subject.lcc | LD5655.V856 1986.B766 | en |
| dc.subject.lcsh | Appetite stimulants | en |
| dc.subject.lcsh | Hypothalamus | en |
| dc.title | Hypothalamic beta-endorphin, body weight, and food intake in ovarian steroid treated rats | en |
| dc.type | Dissertation | en |
| dc.type.dcmitype | Text | en |
| thesis.degree.discipline | Human Nutrition and Foods | en |
| thesis.degree.grantor | Virginia Polytechnic Institute and State University | en |
| thesis.degree.level | doctoral | en |
| thesis.degree.name | Ph. D. | en |
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