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Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysis

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dc.contributor.authorEvans-Hoeker, Emilyen
dc.contributor.authorWang, Zhengen
dc.contributor.authorGroen, Henken
dc.contributor.authorCantineau, Astrid E. P.en
dc.contributor.authorThurin-Kjellberg, Annen
dc.contributor.authorBergh, Christinaen
dc.contributor.authorLaven, Joop S. E.en
dc.contributor.authorDietz De Loos, Alexandraen
dc.contributor.authorJiskoot, Geranneen
dc.contributor.authorBaillargeon, Jean-Patriceen
dc.contributor.authorPalomba, Stefanoen
dc.contributor.authorSim, Kyraen
dc.contributor.authorMoran, Lisa J.en
dc.contributor.authorEspinós, Juan J.en
dc.contributor.authorMoholdt, Trineen
dc.contributor.authorRothberg, Amy E.en
dc.contributor.authorShoupe, Donnaen
dc.contributor.authorHoek, Annemiekeen
dc.contributor.authorLegro, Richard S.en
dc.contributor.authorMol, Ben W.en
dc.contributor.authorWang, Ruien
dc.date.accessioned2023-02-01T17:02:04Zen
dc.date.available2023-02-01T17:02:04Zen
dc.date.issued2022-11-07en
dc.date.updated2023-02-01T15:37:15Zen
dc.description.abstractIntroduction: Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions). Methods and analysis: We will include RCTs with dietary and/or physical activity interventions as core interventions prior to fertility treatment in women with infertility and overweight or obesity. The primary outcome will be live birth. We will search MEDLINE, Embase, Cochrane Central Register of Controlled Trials and trial registries to identify eligible studies. We will approach authors of eligible trials to contribute individual participant data (IPD). We will perform risk of bias assessments according to the Risk of Bias 2 tool and a random-effects IPDMA. We will then explore treatment-covariate interactions for important participant-level characteristics. Ethics and dissemination: Formal ethical approval for the project (Venus-IPD) was exempted by the medical ethics committee of the University Medical Center Groningen (METc code: 2021/563, date: 17 November 2021). Data transfer agreement will be obtained from each participating institute/hospital. Outcomes will be disseminated internationally through the collaborative group, conference presentations and peer-reviewed publication. PROSPERO registration number CRD42021266201.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2022-065206en
dc.identifier.eissn2044-6055en
dc.identifier.issn2044-6055en
dc.identifier.issue11en
dc.identifier.orcidEvans-Hoeker, Emily [0000-0001-6168-5347]en
dc.identifier.otherbmjopen-2022-065206 (PII)en
dc.identifier.pmid36344004en
dc.identifier.urihttp://hdl.handle.net/10919/113612en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherBMJen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/36344004en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectVenus-IPD Collaborationen
dc.subjectNutrition & dieteticsen
dc.subjectPerinatologyen
dc.subjectReproductive medicineen
dc.subjectSubfertilityen
dc.subjectInfertilityen
dc.subjectNutritionen
dc.subjectContraception/Reproductionen
dc.subjectComparative Effectiveness Researchen
dc.subjectObesityen
dc.subjectClinical Trials and Supportive Activitiesen
dc.subjectClinical Researchen
dc.subjectPreventionen
dc.subjectCardiovascularen
dc.subjectReproductive health and childbirthen
dc.subjectStrokeen
dc.subjectCanceren
dc.subject.meshHumansen
dc.subject.meshInfertilityen
dc.subject.meshObesityen
dc.subject.meshExerciseen
dc.subject.meshDieten
dc.subject.meshPregnancyen
dc.subject.meshFemaleen
dc.subject.meshOverweighten
dc.subject.meshMeta-Analysis as Topicen
dc.subject.meshSystematic Reviews as Topicen
dc.titleDietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysisen
dc.title.serialBMJ Openen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/OB GYNen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/OB GYN/Reproductive Medicineen

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