Neuroblast migration along cellular substrates in the developing porcine brain

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dc.contributor.authorPorter, Demisha D. L.en
dc.contributor.authorHenry, Sara N.en
dc.contributor.authorAhmed, Sadiaen
dc.contributor.authorRizzo, Amy L.en
dc.contributor.authorMakhlouf, Ritaen
dc.contributor.authorGregg, Collinen
dc.contributor.authorMorton, Paul D.en
dc.date.accessioned2023-05-09T17:53:14Zen
dc.date.available2023-05-09T17:53:14Zen
dc.date.issued2022-09en
dc.description.abstractIn the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models. We reasoned that migratory streams of neuroblasts utilize cellular substrates, such as blood vessels, to guide their trek from the subventricular zone to distant cortical targets. Here, we evaluate the association between young interneuronal migratory streams and their preferred cellular substrates in gyrencephalic piglets during the developmental equivalent of human birth, infancy, and toddlerhood.en
dc.description.notesACKNOWLEDGMENTS We gratefully thank Drs. Sherrie Clark-Deener and Calvin Lau for their assistance with veterinary services. We are also thankful to Jessica Neary and Garrett Walker for assistance in animal husband-ry. We also would like to thank Raymundo Hernandez, Beatriz Torres, Swagatika Paul, and Dr. Alicia Pickrell for technical advice. We would like to acknowledge Karen Hall and Rachel McNeil for animal care. This work was supported by the US National Institutes of Health (R15NS108183 to P.D.M.) .en
dc.description.sponsorshipUS National Institutes of Health [R15NS108183]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.stemcr.2022.07.015en
dc.identifier.issue9en
dc.identifier.pmid35985331en
dc.identifier.urihttp://hdl.handle.net/10919/114993en
dc.identifier.volume17en
dc.language.isoenen
dc.publisherCell Pressen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNeural stem-cellsen
dc.subjectsubventricular zoneen
dc.subjectadult neurogenesisen
dc.subjectneuronsen
dc.subjectvasculatureen
dc.subjectforebrainen
dc.subjectscaffolden
dc.subjectcolocalizationen
dc.subjectconsequencesen
dc.subjectparvalbuminen
dc.titleNeuroblast migration along cellular substrates in the developing porcine brainen
dc.title.serialStem Cell Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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