Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains

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dc.contributor.authorSuarez-Esquivel, Marcelaen
dc.contributor.authorRuiz-Villalobos, Nazarethen
dc.contributor.authorCastillo-Zeledon, Amandaen
dc.contributor.authorJimenez-Rojas, Cesaren
dc.contributor.authorRoop, R. Martin IIen
dc.contributor.authorComerci, Diego J.en
dc.contributor.authorBarquero-Calvo, Eliasen
dc.contributor.authorChacon-Diaz, Carlosen
dc.contributor.authorCaswell, Clayton C.en
dc.contributor.authorBaker, Kate S.en
dc.contributor.authorChaves-Olarte, Estebanen
dc.contributor.authorThomson, Nicholas R.en
dc.contributor.authorMoreno, Edgardoen
dc.contributor.authorLetesson, Jean J.en
dc.contributor.authorDe Bolle, Xavieren
dc.contributor.authorGuzman-Verri, Caterinaen
dc.date.accessioned2019-03-14T19:33:15Zen
dc.date.available2019-03-14T19:33:15Zen
dc.date.issued2016-09-29en
dc.description.abstractBrucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en.wikipedia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available 2308 genomes showed significant differences, particularly indels related to insertional elements, suggesting variability related to the transposition of these elements within the same strain. Considering the outcome of high resolution genomic techniques in the bacteriology field, the conventional concept of strain definition needs to be revised.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2016.01557en
dc.identifier.issn1664-302Xen
dc.identifier.other1557en
dc.identifier.pmid27746773en
dc.identifier.urihttp://hdl.handle.net/10919/88449en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleBrucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strainsen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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