Mathematical model of the morphogenesis checkpoint in budding yeast

Simple item page
dc.contributor.authorCiliberto, Andreaen
dc.contributor.authorNovak, Belaen
dc.contributor.authorTyson, John J.en
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2016-12-09T21:26:48Zen
dc.date.available2016-12-09T21:26:48Zen
dc.date.issued2003-12-22en
dc.description.abstractThe morphogenesis checkpoint in budding yeast delays progression through the cell cycle in response to stimuli that prevent bud formation. Central to the checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts cell cycle progression in G2. We propose a molecular network for Swe1 control, based on published observations of budding yeast and analogous control signals in fission yeast. The proposed Swe1 network is merged with a model of cyclin-dependent kinase regulation, converted into a set of differential equations and studied by numerical simulation. The simulations accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.en
dc.description.versionPublished versionen
dc.format.extent1243 - 1254 (12) page(s)en
dc.identifier.doihttps://doi.org/10.1083/jcb.200306139en
dc.identifier.issn0021-9525en
dc.identifier.issue6en
dc.identifier.urihttp://hdl.handle.net/10919/73619en
dc.identifier.volume163en
dc.languageEnglishen
dc.publisherRockefeller University Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000187583500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectCell Biologyen
dc.subjectmolecular networksen
dc.subjectdynamical systemsen
dc.subjectcell cycleen
dc.subjectsize controlen
dc.subjectSwel kinaseen
dc.subjectCELL-CYCLEen
dc.subjectSACCHAROMYCES-CEREVISIAEen
dc.subjectTYROSINE PHOSPHORYLATIONen
dc.subjectSWE1P DEGRADATIONen
dc.subjectS-PHASEen
dc.subjectKINASEen
dc.subjectMECHANISMSen
dc.subjectMITOSISen
dc.subjectWEE1en
dc.subjectCONSERVATIONen
dc.titleMathematical model of the morphogenesis checkpoint in budding yeasten
dc.title.serialJournal of Cell Biologyen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Mathematical model of the morphogenesis checkpoint in budding yeast.pdf
Size:
224.11 KB
Format:
Adobe Portable Document Format
Description:
Publisher's Version
Download
License bundle
Now showing 1 - 1 of 1
Name:
VTUL_Distribution_License_2016_05_09.pdf
Size:
18.09 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, Biological Sciences