Genome-Wide Effects of Long-Term Divergent Selection

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dc.contributor.authorJohansson, Anna M.en
dc.contributor.authorPettersson, Mats E.en
dc.contributor.authorSiegel, Paul B.en
dc.contributor.authorCarlborg, Örjanen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2019-10-23T13:31:56Zen
dc.date.available2019-10-23T13:31:56Zen
dc.date.issued2010-11en
dc.description.abstractTo understand the genetic mechanisms leading to phenotypic differentiation, it is important to identify genomic regions under selection. We scanned the genome of two chicken lines from a single trait selection experiment, where 50 generations of selection have resulted in a 9-fold difference in body weight. Analyses of nearly 60,000 SNP markers showed that the effects of selection on the genome are dramatic. The lines were fixed for alternative alleles in more than 50 regions as a result of selection. Another 10 regions displayed strong evidence for ongoing differentiation during the last 10 generations. Many more regions across the genome showed large differences in allele frequency between the lines, indicating that the phenotypic evolution in the lines in 50 generations is the result of an exploitation of standing genetic variation at 100s of loci across the genome.en
dc.description.notesFunding was provided by the Swedish Foundation for Strategic Research (http://www.stratresearch.se), a EURYI Award from ESF (http://www.esf.org), and a postdoctoral grant from the Swedish Research Council (http://www.vr.se). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipSwedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research; ESFEuropean Science Foundation (ESF)European Social Fund (ESF); Swedish Research CouncilSwedish Research Councilen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pgen.1001188en
dc.identifier.issn1553-7404en
dc.identifier.issue11en
dc.identifier.othere1001188en
dc.identifier.pmid21079680en
dc.identifier.urihttp://hdl.handle.net/10919/95039en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherPLoSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleGenome-Wide Effects of Long-Term Divergent Selectionen
dc.title.serialPLOS Geneticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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