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Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome

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dc.contributor.authorKahanovitch, Urien
dc.contributor.authorPatterson, Kelsey C.en
dc.contributor.authorHernandez, Raymundo D.en
dc.contributor.authorOlsen, Michelle L.en
dc.contributor.departmentSchool of Neuroscienceen
dc.date.accessioned2019-08-09T12:25:58Zen
dc.date.available2019-08-09T12:25:58Zen
dc.date.issued2019-08-05en
dc.date.updated2019-08-09T08:01:55Zen
dc.description.abstractRett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting females, resulting in a range of symptoms including autistic features, intellectual impairment, motor deterioration, and autonomic abnormalities. RTT is primarily caused by the genetic mutation of the Mecp2 gene. Initially considered a neuronal disease, recent research shows that glial dysfunction contributes to the RTT disease phenotype. In the following manuscript, we review the evidence regarding glial dysfunction and its effects on disease etiology.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKahanovitch, U.; Patterson, K.C.; Hernandez, R.; Olsen, M.L. Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome. Int. J. Mol. Sci. 2019, 20, 3813.en
dc.identifier.doihttps://doi.org/10.3390/ijms20153813en
dc.identifier.urihttp://hdl.handle.net/10919/93016en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectastrocytesen
dc.subjectoligodendrocytesen
dc.subjectmicrogliaen
dc.titleGlial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndromeen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, School of Neuroscience