Toward the design, synthesis and evaluation of Protein Kinase C inhibitors

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dc.contributor.authorHubieki, Marina Patriciaen
dc.contributor.committeechairGandour, Richard D.en
dc.contributor.committeememberHudlicky, Tomasen
dc.contributor.committeememberBrewer, Karen J.en
dc.contributor.committeememberCastagnoli, Neal Jr.en
dc.contributor.committeememberTanko, James M.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:23:05Zen
dc.date.adate2005-11-10en
dc.date.available2014-03-14T21:23:05Zen
dc.date.issued1996-04-14en
dc.date.rdate2005-11-10en
dc.date.sdate2005-11-10en
dc.description.abstractProtein Kinase C (PKC) represents an important regulatory element in the signal transduction pathways of mammalian cells. Research interest has increased enormously since the discovery that PKC plays critical roles in cell differentiation, tumor promotion, oncogenesis and cell regulatory processes. The primary driving force of this project was the study and development of enantioselective PKC inhibitors. To accomplish this objective the four stereoisomers, (2S/4S)-, (2RI4S)-, (2R14R)-, and (2S/4R)-6-N,N-dimethyl-2-methyl-2-oxo-l,3-dioxa- 4-pentadecyl-6-aza-2-phosphacyclooctane bromides (la-d) were synthesized and evaluated. Long-alkyl chain optically pure epoxides, the key intermediates for the synthesis, were prepared from relatively inexpensive glyceraldehyde surrogates. Several other intermediates exhibited other biological responses including spermicidal, anti-HIV, mycobactericidal, and anti-cancer activities.en
dc.description.degreePh. D.en
dc.format.extentvi, 176 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-11102005-141121en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-11102005-141121/en
dc.identifier.urihttp://hdl.handle.net/10919/40315en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1996.H835.pdfen
dc.relation.isformatofOCLC# 34996399en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectregulatory elementsen
dc.subject.lccLD5655.V856 1996.H835en
dc.titleToward the design, synthesis and evaluation of Protein Kinase C inhibitorsen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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