Dynamical modeling of syncytial mitotic cycles in Drosophila embryos

dc.contributor.authorCalzone, Laurenceen
dc.contributor.authorThieffry, Denisen
dc.contributor.authorTyson, John J.en
dc.contributor.authorNovak, Belaen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2016-12-09T21:34:06Zen
dc.date.available2016-12-09T21:34:06Zen
dc.date.issued2007-07-01en
dc.description.abstractImmediately following fertilization, the fruit fly embryo undergoes 13 rapid, synchronous, syncytial nuclear division cycles driven by maternal genes and proteins. During these mitotic cycles, there are barely detectable oscillations in the total level of B-type cyclins. In this paper, we propose a dynamical model for the molecular events underlying these early nuclear division cycles in Drosophila. The model distinguishes nuclear and cytoplasmic compartments of the embryo and permits exploration of a variety of rules for protein transport between the compartments. Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. The model can be used to predict the phenotypes of novel mutations and effective ranges of the unmeasured rate constants and transport coefficients in the proposed mechanism.en
dc.description.versionPublished versionen
dc.format.extent? - ? (11) page(s)en
dc.identifier.doihttps://doi.org/10.1038/msb4100171en
dc.identifier.issn1744-4292en
dc.identifier.urihttp://hdl.handle.net/10919/73630en
dc.identifier.volume3en
dc.languageEnglishen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000248492100008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectcell cycleen
dc.subjectcyclin Ben
dc.subjectDrosophila developmenten
dc.subjectmathematical modelingen
dc.subjectstringen
dc.subjectDNA-REPLICATION CHECKPOINTen
dc.subjectXENOPUS-OOCYTE EXTRACTSen
dc.subjectM-PHASE CONTROLen
dc.subjectCELL-CYCLEen
dc.subjectMIDBLASTULA TRANSITIONen
dc.subjectDEGRADATIONen
dc.subjectEGGSen
dc.subjectEMBRYOGENESISen
dc.subjectMELANOGASTERen
dc.subjectMITOSISen
dc.titleDynamical modeling of syncytial mitotic cycles in Drosophila embryosen
dc.title.serialMOLECULAR SYSTEMS BIOLOGYen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen
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